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Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model
(
Wiley
, 2020 , Article)
© 2020 Wiley Periodicals, Inc. Myosin-binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex cardiac disorder due to its significant genetic and clinical ...
Electrospun polylactic acid/date palm polyphenol extract nanofibres for tissue engineering applications
(
Springer
, 2019 , Article)
In this study, a set of polylactic acid (PLA)/polyphenol extracted from date palm fruit (DP) blends were prepared by electrospinning process to be used as cell culture scaffolds for tissue engineering applications. For ...
Autoimmune Diseases of the GI Tract Part I: Etiology and Pathophysiology
(
IntechOpen
, 2022 , Book chapter)
Autoimmune diseases have emerged as a pandemic in our modern societies, especially after World War II. There are currently more than 80 autoimmune diseases that compromise the lives of millions of patients around the world. ...
Autoimmune Diseases of the GI Tract Part II: Emergence of Diagnostic Tools and Treatments
(
IntechOpen
, 2022 , Book chapter)
Autoimmune diseases (AD) have emerged as a pandemic in our modern societies, especially after the World War II. In part I, we have reviewed five main diseases and shed light on different aspects from introducing the concept ...
Nanotechnology in medicine – our experiences
(
Macedonian Pharmaceutical Association
, 2022 , Article)
The success of design criteria for long-circulating drug delivery systems to support membrane receptor-ligand interaction and internalization has been limited and there is a need to develop smarter approaches for efficient ...
Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors
(
Springer
, 2023 , Article Review)
Sodium-glucose co-transporter 2 (SGLT2) inhibitors represent one type of new-generation type 2 diabetes (T2DM) drug treatment. The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on lowering ...
Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling
(
Elsevier
, 2017 , Article)
Aortic valve diseases are among the most common cardiovascular defects. Since a non-functioning valve results in disturbed blood flow conditions, the diagnosis of such defects is based on identification of stenosis via ...
Minimally Invasive and Non-Invasive Technologies for Predicting Heart Failure
(
Wiley
, 2022 , Book chapter)
Heart failure is a life-threatening medical problem which refers to inadequate blood supply to body tissues due to the limited functioning of heart muscles. Heart failure is mostly observed as a chronic disease which ...
Latest Developments in Adapting Deep Learning for Assessing TAVR Procedures and Outcomes
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2023 , Article)
Aortic valve defects are among the most prevalent clinical conditions. A severely damaged
or non-functioning aortic valve is commonly replaced with a bioprosthetic heart valve (BHV) via the
transcatheter aortic valve ...
The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
(
Springer
, 2023 , Article Review)
Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ...