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Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses.
(
Nature Research
, 2019 , Article)
The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide ...
Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation
(
Nature Publishing Group
, 2016 , Article)
Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B ...
Impact of physical exercise on gut microbiome, inflammation, and the pathobiology of metabolic disorders
(
Society for Biomedical Diabetes Research
, 2019 , Article)
BACKGROUND: The gastrointestinal tract (GIT) harbors a complex and diverse microbial composition that outnumbers our own body cells and their gene contents. These microbes play a significant role in host metabolism and ...
Predictive Biomarkers of Intensive Care Unit and Mechanical Ventilation Duration in Critically-Ill Coronavirus Disease 2019 Patients.
(
Frontiers Media
, 2021 , Article)
Detection of early metabolic changes in critically-ill coronavirus disease 2019 (COVID-19) patients under invasive mechanical ventilation (IMV) at the intensive care unit (ICU) could predict recovery patterns and help in ...
Visfatin : An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases
(
Wiley
, 2021 , Article)
Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular ...
Molecular and biological characterization of influenza A viruses isolated from human fecal samples
(
Elsevier
, 2021 , Article)
Human influenza viruses are occasionally detected in the stools of influenza patients. Objectives: Here, we investigated the molecular and biological characteristics of intestinal influenza viruses and their potential role ...
Reinfections in COVID-19 Patients: Impact of Virus Genetic Variability and Host Immunity
(
MDPI
, 2021 , Article)
The COVID-19 pandemic is still posing a devastating threat to social life and economics. Despite the modest decrease in the number of cases during September-November 2020, the number of active cases is on the rise again. ...
Molecular and Biological Mechanisms Underlying Gender Differences in COVID-19 Severity and Mortality
(
Frontiers Media
, 2021 , Article)
Globally, over two million people have perished due to the recent pandemic caused by SARS-CoV-2. The available epidemiological global data for SARS-CoV-2 portrays a higher rate of severity and mortality in males. Analyzing ...
Profiling of intestinal microbiota in patients infected with respiratory influenza a and b viruses
(
MDPI
, 2021 , Article)
Little is known about the association between respiratory viral infections and their impact on intestinal microbiota. Here, we compared the effect of influenza types, A and B, and influenza shedding in patients’ stools on ...
Epidemiology Profile of Viral Meningitis Infections Among Patients in Qatar (2015-2018)
(
Frontiers Media
, 2021 , Article)
Little is known about the etiology of meningitis in the MENA region, including Qatar. Viral agents are considered the major cause for meningitis worldwide. Here, we present primary data about the etiology and clinical and ...