Biomedical Research Center: Recent submissions
Now showing items 1-20 of 805
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Exploring the link between environmental chemical exposures and epigenetic modifications in diabetes mellitus.
( The Association of Basic Medical Sciences , 2025 , Article Review)Diabetes mellitus (DM) is a globally prevalent metabolic disorder characterized by impaired glucose homeostasis and insulin secretion. Beyond traditional risk factors like lifestyle and genetics, environmental pollutants, ... -
Comprehensive analysis of human coronavirus antibody responses in ICU and non-ICU COVID-19 patients reveals IgG3 against SARS-CoV-2 spike protein as a key biomarker of disease severity
( Microbiology Society , 2025 , Article)Introduction. Pre-existing immunity to human coronaviruses (HCoVs) may shape the immune response in COVID-19 patients. Increasing evidence suggests that immune cross-reactivity between SARS-CoV-2 and other coronaviruses ... -
Antibody-dependent enhancement of SARS-CoV-2, the impact of variants and vaccination
( Taylor and Francis Group , 2025 , Article)This study characterized antibody-dependent enhancement (ADE) in serum samples from individuals exposed to SARS-CoV-2 via infection or vaccination and evaluated its association with SARS-CoV-2 variants (Wuhan and Omicron), ... -
The impact of pre-existing immunity on the emergence of within-host immune-escape mutations in Omicron lineages
( Microbiology Society , 2025 , Article)The Omicron variant of SARS-CoV-2 circulating amongst highly immunized populations is anticipated to induce immunological pressures, potentially compromising existing immunity. This study investigates vaccine-induced ... -
Glucosamine Schiff bases as fluorescent sensors for recognition of Al+3 and Zn+2 ions
( Elsevier , 2025 , Article)Glucosamine salicylidene (GAS) and Glucosamine-4-nitrosalicylidene (GANS) were synthesized using microwave and investigated as water-soluble chemosensors for aluminum and zinc ions. UV–vis, fluorescence titration, binding ... -
Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1? Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ... -
Protection conferred by SARS-CoV-2 infection across a spectrum of reinfection symptoms and severities
( BMJ Publishing Group , 2025 , Article)Background SARS-CoV-2 infection is associated with protection against reinfection. This study analysed this protection across different reinfection symptoms and severities, comparing the preomicron and omicron eras. Methods ... -
N-Lactoyl amino acids as metabolic biomarkers differentiating low and high exercise response
( Institute of Sport , 2025 , Article)Aerobic physical exercise has significant benefits for cardiovascular health; however, some individuals experience no benefit or even adverse effects. One reason for poor tolerance to aerobic exercise may be a low percentage ... -
A Snapshot of Antimicrobial Resistance in Semi-Wild Oryx: Baseline Data from Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background/Objectives: The spread of antimicrobial resistance (AMR) is a growing global health concern. Wild animals can play an important role in the amplification and dissemination of AMR and in conservation efforts ... -
Accre 8 emerging point of care CLIA system for vitamin B12 assessment compared with three established assays
( Nature Research , 2025 , Article)Accurate Vitamin B12 (Vit B12) quantification is essential for diagnosing deficiencies linked to neurological and hematological disorders. The Accre 8 Point-of-Care (POC) Chemiluminescent Immunoassay (CLIA) system offers ... -
Indoleacetylglutamine Pathway Is a Potential Biomarker for Cardiovascular Diseases
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality. Metabolomics allows for the identification of important biomarkers for CVDs, essential for early detection and risk assessment. This ... -
Silicone Quaterium-22 Surfactant as an Eco-Friendly Carbon Steel Anticorrosive: Assessment of Corrosion Inhibition Properties and Ecotoxicity in Zebrafish Embryos
( Elsevier , 2025 , Article)Corrosion of carbon steel pipelines in the oil and gas industry presents operational and environmental challenges, requiring safer alternatives to toxic corrosion inhibitors. This study evaluates Silicon-Q-22 (SQ22) as a ... -
Optimization of UAE of phenolic and antioxidant compounds from Ephedra foeminea by RSM
( Qatar University , 2025 , Poster)Ephedra foeminea Forssk, a widely distributed shrub in the East Mediterranean, possesses numerous traditional medicinal applications and is an abundant source of bioactive phytochemical metabolites. In this study, ult ... -
Utilization of Complementary Medicine Among Type 2 Diabetes Patients in Qatar: A Cross Sectional Study
( Elsevier , 2025 , Article)BackgroundDiabetes Mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels due to inadequate insulin production or ineffective insulin utilization. The prevalence of DM is rising globally, ... -
Phytochemical Composition and Anticancer Properties of Haplophyllum tuberculatum Growing in Qatar and Oman Against Human Triple-Negative Breast Cancer Cells
( Qatar University , 2025 , Poster)Introduction: Breast cancer ranks as the most frequently diagnosed cancer globally, with the triple-negative breast cancer (TNBC) subtype linked to a notably poor prognosis. The absence of optimal therapeutic regimens ... -
Developmental toxicity of Peganum harmala seed extractsin zebrafish embryos
( Qatar University , 2025 , Poster)Introduction: Peganum harmala L. is a widely utilized plant in traditional medicine in many countries, including Qatar. Nevertheless, there have been several reports of toxic effects associated with the use of P. harmala ... -
Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study
( MDPI , 2025 , Article)Background: Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ... -
Characterization of Anti-Cancer Properties of Qatari Prosopis Species, Prosopis juliflora and Prosopis cineraria, against Human Breast, Lung, and Ovarian Cancer Cell Lines
( Qatar University , 2025 , Poster)Background: The Prosopis plant species have been reported for their diverse therapeutic benefits, including anti-inflammatory, anti-microbial, antioxidant, and anti- tumor properties. Prosopis cineraria, Prosopis ... -
A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
( Elsevier , 2025 , Article)Here, we report the engineering of a Bioluminescence Resonance Energy Transfer (BRET)-based SARS-CoV-2 main protease (Mpro) biosensor containing the Mpro N-terminal autocleavage sequence in tandem and a nanobody that shows ... -
Intravenous administration of gold nanoparticles in rats exhibit alterations in sphingomyelins, bile acids, sphingolipids, and cholesterol esters levels
( Springer , 2025 , Article)Nanoparticles (NP) have gained significant attention in biomedical research due to their unique properties and potential applications in drug delivery, imaging, and diagnostics. Gold (AuNPs) and silver (AgNPs) NPs are among ...
