Biomedical Research Center: Recent submissions
Now showing items 281-300 of 738
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Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model.
( MDPI , 2022 , Article)Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells' proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their ... -
Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 omicron infections.
( Oxford University Press , 2022 , Article)Compared to BA.1, BA.2 was associated with lower RT-qPCR cycle threshold (Ct) value-3.53 fewer cycles (95% CI: 3.46-3.60), signifying higher infectiousness. This may reflect higher viral load and/or longer duration of ... -
Transmissibility and Persistence of the Plasmid-Borne Mobile Colistin Resistance Gene, mcr-1, Harbored in Poultry-Associated E. coli
( MDPI , 2022 , Article)Colistin, a last-resort antibiotic, is used to treat infections caused by multi-drug-resistant Gram-negative bacteria. Colistin resistance can emerge by acquiring the mobile colistin gene, mcr-1, usually plasmid borne. ... -
Retail Chicken Carcasses as a Reservoir of Multidrug-Resistant .
( Mary Ann Liebert , 2022 , Article)is a major cause of foodborne disease outbreaks worldwide, mainly through poultry. Recently, there has been an increase in multidrug-resistant (MDR) infections globally. The increased drug resistance results in increased ... -
Bacterial indoor air contaminations in hospitals in MENA region: a systematic review
( Taylor and Francis , 2022 , Article Review)Poor indoor air quality in healthcare settings has been tied with the increase in hospital-acquired infections. Thus, this systematic review was conducted to assess the levels and compositions of bacteria in indoor hospital ... -
Variations in respiratory syncytial virus activity following the relaxation of COVID-19 restrictions in Qatar.
( Oxford University Press , 2022 , Article)Despite the relaxation of COVID-19 restrictions in Qatar in October-December 2020, the detection of RSV was reduced ∼25-fold compared with 2019. This dramatic decrease during the typical RSV season could be related to ... -
The Effects of Class IV Hemorrhagic Hypotensive Shock and Its Resuscitation with Fluids and Adjuvant Vasopressors or Cellular Energy Replenishment on the Splanchnic Microcirculation
( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Traumatic exsanguination leading to class IV hemorrhagic shock as defined by the Committee on Trauma of the American College of Surgeons requires aggressive resuscitation with crystalloids and packed cells together with ... -
A comprehensive review summarizing the recent biomedical applications of functionalized carbon nanofibers
( John Wiley and Sons Inc , 2021 , Article)Since the discovery and fabrication of carbon nanofibers (CNFs) over a decade ago, scientists foster to discover novel myriad potential applications for this material in both biomedicine and industry. The unique economic ... -
Activation and Contraction of Human “Vascular” Smooth Muscle Cells Grown From Circulating Blood Progenitors
( Frontiers Media , 2021 , Article)Blood outgrowth smooth muscle cells (BO-SMCs) offer the means to study vascular cells without the requirement for surgery providing opportunities for drug discovery, tissue engineering, and personalized medicine. However, ... -
Solar cultivation of microalgae in a desert environment for the development of techno-functional feed ingredients for aquaculture in Qatar
( Elsevier , 2022 , Article)The demand for aquaculture feed will increase in the coming years in order to ensure food security for a growing global population. Microalgae represent a potential fish-feed ingredient; however, the feasibility of their ... -
Soluble ACE2 and angiotensin II levels are modulated in hypertensive COVID-19 patients treated with different antihypertension drugs.
( Taylor and Francis , 2022 , Article)This study examines the effect of antihypertensive drugs on ACE2 and Angiotensin II levels in hypertensive COVID-19 patients. Hypertension is a common comorbidity among severe COVID-19 patients. ACE2 expression can be ... -
Assessment of the Neutralizing Antibody Response of BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines in Naïve and Previously Infected Individuals: A Comparative Study
( MDPI , 2022 , Report)The currently authorized mRNA COVID-19 vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, offer great promise for reducing the spread of the COVID-19 by generating protective immunity against SARS-CoV-2. Recently, it was ... -
Blood Flow Disturbance and Morphological Alterations Following the Right Atrial Ligation in the Chick Embryo.
( Frontiers Media , 2022 , Article)Collectively known as congenital heart defects (CHDs), cardiac abnormalities at birth are the most common forms of neonatal defects. Being principally responsible for the heart's pumping power, ventricles are particularly ... -
Antibacterial and Antibiofilm Activity of Mercaptophenol Functionalized-Gold Nanorods Against a Clinical Isolate of Methicillin-Resistant Staphylococcus aureus
( Springer , 2022 , Article)Gold nanorods (AuNRs) were synthesized by the seed-mediated wet chemical method using a binary surfactant system. AuNRs were stabilized with polyethylene glycol, then functionalized with 4-mercaptophenol (4-MPH) ligand by ... -
Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
( Elsevier , 2022 , Article Review)Over the past two decades, diabetes mellitus (DM) has been receiving increasing attention among autoimmune diseases. The prevalence of type 1 and type 2 diabetes has increased rapidly and has become one of the leading ... -
Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains
( Medknow Publications , 2021 , Article)Sperm-specific phospholipase C zeta (PLC) initiates intracellular calcium (Ca2+) transients which drive a series of concurrent events collectively termed oocyte activation. Numerous investigations have linked abrogation ... -
Pyridoxine non-responsive p.R336C mutation alters the molecular properties of cystathionine beta-synthase leading to severe homocystinuria phenotype
( Elsevier , 2022 , Article)The prevalence of homocystinuria in Qatar is 1:1800, mainly due to a founder missense mutation p.R336C. • The cystathionine beta-synthase (CBS) R336C mutant was bacterially expressed, purified and its molecular properties ... -
Evaluation of Metal-Organic Framework MIL-89 Nanoparticles Toxicity on Embryonic Zebrafish Development
( Elsevier , 2022 , Article)Metal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still ... -
Hemodynamic and Structural Comparison of Human Fetal Heart Development Between Normally Growing and Hypoplastic Left Heart Syndrome-Diagnosed Hearts
( Frontiers Media , 2022 , Article)Congenital heart defects (CHDs) affect a wide range of societies with an incidence rate of 1.0–1.2%. These defects initiate at the early developmental stage and result in critical health disorders. Although genetic factors ... -
Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms.
( Bentham Science Publishers , 2022 , Article Review)Microglia are the resident immune cells of the brain and play a crucial role in housekeeping and maintaining homeostasis of the brain microenvironment. Upon injury or disease, microglial cells become activated, at least ...
