Biomedical Research Center: Recent submissions
Now showing items 541-560 of 738
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Gene expression and miRNAs profiling: Function and regulation in human epidermal growth factor receptor 2 (HER2) - positive breast cancer
( MDPI AG , 2019 , Article)Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 ... -
The Spectrum of Mutations of Homocystinuria in the MENA Region
( MDPI , 2020 , Article Review)Homocystinuria is an inborn error of metabolism due to the deficiency in cystathionine beta-synthase (CBS) enzyme activity. It leads to the elevation of both homocysteine and methionine levels in the blood and urine. ... -
Crosstalk between HER2 and PD-1/PD-L1 in Breast Cancer: From Clinical Applications to Mathematical Models.
( Springer , 2020 , Article)Breast cancer is one of the major causes of mortality in women worldwide. The most aggressive breast cancer subtypes are human epidermal growth factor receptor-positive (HER2) and triple-negative breast cancers. Therapies ... -
Antibiotic resistance and virulence patterns of pathogenic Escherichia coli strains associated with acute gastroenteritis among children in Qatar
( BMC , 2020 , Article)Background: The treatment of Enterobacteriaceae family including diarrheagenic E. coli (DEC) has been increasingly complicated due to the emergence of resistant strains. Here we report on the phenotypic resistance profiles ... -
Antibiotic resistance profile of commensal Escherichia coli isolated from healthy sheep in Qatar
(2020 , Article)Introduction: The uncontrolled antibiotics use in livestock is a leading factor for the emergence and spread of resistant bacteria from food animals to humans through the food chain. This study aims at evaluating the ... -
Editorial: Arterial aging and age-associated arterial diseases
( Frontiers Media S.A. , 2018 , Article)[No abstract available] -
The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis.
( Springer , 2020 , Article)Iron is an important component of the oxygen-binding proteins and may be critical to optimal athletic performance. Previous studies have suggested that the G allele of C/G rare variant (rs1799945), which causes H63D amino ... -
Advanced blood flow assessment in Zebrafish via experimental digital particle image velocimetry and computational fluid dynamics modeling
( Elsevier , 2020 , Article)Over the past few decades, Zebrafish has become a widely used vertebrate model for cardiovascular research. Easy genetic manipulation, low cost, high fecundity, embryonic transparency, and ability to survive in the early ... -
Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance.
( Nature Research , 2019 , Article)Genetic research of elite athletic performance has been hindered by the complex phenotype and the relatively small effect size of the identified genetic variants. The aims of this study were to identify genetic predisposition ... -
Seroprevalence of herpes simplex virus types 1 and 2 in Indian and Filipino migrant populations in Qatar: a cross-sectional survey
( World Health Organization , 2018 , Article)Background: The epidemiology of herpes simplex virus infections is of growing interest but information on its seroprevalence in many countries is scarce. Aims: This study aimed to measure the seroprevalence of herpes ... -
Qatar Biobank: A Paradigm of Translating Biobank Science into Evidence-Based Health Care Interventions
( Mary Ann Liebert , 2019 , Article)Biobank science is progressively becoming indispensable for the development of novel diagnostic tools in health care, by pairing standardized high-quality biological samples, phenotypic, and omics data required to best ... -
Conception, Implementation, and Integration of Heterogenous Information Technology Infrastructures in the Qatar Biobank
( Mary Ann Liebert , 2019 , Article)The overall goal of the Qatar Biobank (QBB) is to collect, manage, and distribute high-quality human biospecimens with appropriate clinical and/or research annotation and associated phenotypic data, aiming to be an important ... -
The Implementation of an Integrated Management System at Qatar Biobank
( Mary Ann Liebert , 2019 , Article)Qatar Biobank (QBB) is a platform that will make vital health research possible through its collection of samples and information on health and lifestyle from the local population of Qatar. The goal of QBB is to collect, ... -
Profiling the Oral Microbiome and Plasma Biochemistry of Obese Hyperglycemic Subjects in Qatar
( MDPI , 2019 , Article)The present study is designed to compare demographic characteristics, plasma biochemistry, and the oral microbiome in obese (N = 37) and lean control (N = 36) subjects enrolled at Qatar Biobank, Qatar. Plasma hormones, ... -
Measuring influenza hemagglutinin (HA) stem-specific antibody-dependent cellular cytotoxicity (ADCC) in human sera using novel stabilized stem nanoparticle probes
( Elsevier , 2019 , Article)BackgroundGenerating vaccine that confers a complete protection is a major goal in designing a universal influenza vaccine. Currently, there is a considerable interest in the broadly neutralizing antibodies (bnAb) targeting ... -
Mediators of Impaired Adipogenesis in Obesity-Associated Insulin Resistance and T2DM
( IntechOpen , 2019 , Book chapter)Obesity has become a global health issue due to its high prevalence and associated comorbidities including insulin resistance (IR) and type 2 diabetes mellitus (T2DM). Obesity is associated with the expansion of adipose ... -
Metabolic profiling of elite athletes with different cardiovascular demand
( John Wiley & Sons Ltd , 2019 , Article)Intensive exercise of elite athletes can lead to physiological alterations in the cardiovascular system in response to increased stroke volume and blood pressure, known collectively as cardiovascular demand (CD). This study ... -
Metabolic signature of obesity-associated insulin resistance and type 2 diabetes.
( BMC , 2019 , Article)Obesity is associated with an increased risk of insulin resistance and type 2 diabetes mellitus (T2DM). However, some obese individuals maintain their insulin sensitivity and exhibit a lower risk of associated comorbidities. ... -
The Current Status of Cytomegalovirus (CMV) Prevalence in the MENA region: a systematic review
( MDPI , 2019 , Article)Human cytomegalovirus (CMV) is a highly prevalent herpesvirus worldwide. According to the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), CMV infects people of all ages, and by ... -
Cryptosporidium spp., prevalence, molecular characterisation and socio-demographic risk factors among immigrants in Qatar.
( Public Library of Science , 2019 , Article)The World Health Organization WHO has estimated that in developed countries, up to 30% of the population may suffer from foodborne diseases each year, and that in developing countries up to 2 million deaths per annum can ...
