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المؤلفHasan, Anwarul
المؤلفSoliman, Sherif
المؤلفEl Hajj, Fatima
المؤلفTseng, Yuan-Tsan
المؤلفYalcin, Huseyin C
المؤلفMarei, Hany Elsayed
تاريخ الإتاحة2018-06-27T05:27:42Z
تاريخ النشر2018-05-01
اسم المنشورScientific Reports
المعرّفhttp://dx.doi.org/10.1038/s41598-018-26452-y
الاقتباسHasan A, Soliman S, El Hajj F, Tseng Y-T, Yalcin HC, Marei HE. Fabrication and In Vitro Characterization of a Tissue Engineered PCL-PLLA Heart Valve. Scientific Reports. 2018;8:8187. doi:10.1038/s41598-018-26452-y.
الرقم المعياري الدولي للكتاب2045-2322
معرّف المصادر الموحدhttp://hdl.handle.net/10576/6751
الملخصHeart valve diseases are among the leading causes of cardiac failure around the globe. Nearly 90,000 heart valve replacements occur in the USA annually. Currently, available options for heart valve replacement include bioprosthetic and mechanical valves, both of which have severe limitations. Bioprosthetic valves can last for only 10-20 years while patients with mechanical valves always require blood-thinning medications throughout the remainder of the patient's life. Tissue engineering has emerged as a promising solution for the development of a viable, biocompatible and durable heart valve; however, a human implantable tissue engineered heart valve is yet to be achieved. In this study, a tri-leaflet heart valve structure is developed using electrospun polycaprolactone (PCL) and poly L-lactic acid (PLLA) scaffolds, and a set of in vitro testing protocol has been developed for routine manufacturing of tissue engineered heart valves. Stress-strain curves were obtained for mechanical characterization of different valves. The performances of the developed valves were hemodynamically tested using a pulse duplicator, and an echocardiography machine. Results confirmed the superiority of the PCL-PLLA heart valve compared to pure PCL or pure PLLA. The developed in vitro test protocol involving pulse duplicator and echocardiography tests have enormous potential for routine application in tissue engineering of heart valves.
اللغةen
الناشرNature Publishing Group
الموضوعPCL-PLLA
Tissue engineering
Polycaprolactone
Coronary heart disease
Surgeons
Polylactic acid
Echocardiography
Catheters
Valves
Heart diseases
العنوانFabrication and In Vitro Characterization of a Tissue Engineered PCL-PLLA Heart Valve.
النوعArticle
الصفحات1-13
رقم العدد1
رقم المجلد8
ESSN2045-2322
dc.accessType Open Access


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