Intranasal and Pulmonary Lipid Nanoparticles for Gene Delivery: Turning Challenges into Opportunities
Date
2025Metadata
Show full item recordAbstract
Delivery of nano-therapeutics through the nasal route offers a promising approach for several applications, including intranasal conditions, pulmonary delivery, brain targeting, and vaccination. Despite its potential, this method faces significant challenges, including overcoming the mucosal barrier, ensuring consistent absorption, controlling the deposition area, and managing immunogenic responses. This review provides a comprehensive overview of the current state of nasally delivered lipid nanoparticles (LNPs) for gene medicine, focusing on the specific barriers encountered in this delivery route and strategies to overcome them. We examine how formulation composition affects stability during aerosolization, analyze the impact of particle characteristics on mucociliary clearance, and evaluate interactions with the lung surfactant layer. The review also compares delivery devices including metered-dose inhalers, dry powder inhalers, and nebulizers, highlighting how device selection influences LNP integrity and deposition patterns. Furthermore, we explore potential safety considerations with intranasal LNPs and propose approaches to mitigate adverse effects. By addressing these challenges with evidence-based strategies, this review aims to advance the development and clinical application of intranasal and pulmonary LNP delivery systems for gene-based therapeutics and vaccines.
Collections
- Biomedical Research Center Research [832 items ]
Related items
Showing items related by title, author, creator and subject.
-
Lipid-based nanoparticles: innovations in ocular drug delivery
Baig, Mirza Salman; Karade, Shweta Kulkarni; Ahmad, Anas; Khan, Mohd Ashif; Haque, Anzarul; Webster, Thomas J; Faiyazuddin, Md; Al-Qahtani, Noora H... more authors ... less authors ( Frontiers Media , 2024 , Article Review)Ocular drug delivery presents significant challenges due to intricate anatomy and the various barriers (corneal, tear, conjunctival, blood-aqueous, blood-retinal, and degradative enzymes) within the eye. Lipid-based ... -
NiFe2O4/poly(ethylene glycol)/lipid-polymer hybrid nanoparticles for anti-cancer drug delivery
Joshy K.S.; Augustine R.; Mayeen A.; Alex S.M.; Hasan, Anwarul; Thomas S.; Chi H.... more authors ... less authors ( Royal Society of Chemistry , 2020 , Article)The present study reports the fabrication of hybrid nanoparticles consisting of nickel ferrite (NFO) for anti cancer drug delivery. The hybrid system was formulated from poly(vinyl alcohol)/stearic acid with PEG containing ... -
Nano-Engineering in Traumatic Brain Injury
Al-Thani, Najlaa; Haider, Mohammad Z.; Al-Mansoob, Maryam; Patel, Stuti; Ahmad, Salma M.S.; Kobeissy, Firas; Shaito, Abdullah... more authors ... less authors ( Wiley , 2023 , Book chapter)Traumatic brain injury (TBI) is a leading cause of mortality and chronic disability worldwide TBI involves an initial primary phase triggered by an impactful force to the brain and a subsequent secondary pathological phase. ...