Laboratory Animal Research Center
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Laboratory Animal Research Center (Research) [163 items ]
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Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study
( Nature Medicine , 2026 , Article)Drug use disorders (DUDs) are emerging global public health challenges. Here we investigated the global and regional estimates of the prevalence and burden of DUDs, including amphetamine, cannabis, cocaine and opioid use ... -
Genetically Encoded Near-Infrared Fluorescent Proteins for Viral Imaging and Detection: A Mini-Review
( Springer Science , 2026 , Article Review)Bacteriophytochrome-derived near-infrared fluorescent proteins (NIR FPs) provide deep tissue penetration, low autofluorescence, and endogenous biliverdin compatibility, enabling non-invasive visualization of viral processes ... -
Targeting 3Cpro of Enterovirus D68 with Medicinal Phytocompounds Using Structure-Based Molecular Screening and Molecular Simulation Approaches to Rescue the Host Immune Response
( Springer Nature , 2026 , Article)Purpose: Enterovirus D68 (EV-D68) is a viral pathogen recognized for its role in inducing severe respiratory illnesses and its link to the development of acute flaccid myelitis (AFM) in children. The 3 C protease (3Cpro) ... -
Exploring the hub gene CERS6 as a therapeutic target in type 1 diabetes through a bioinformatics and network analyst approach
( Nature Research , 2026 , Article)Insulin-producing β-cells are destroyed in type 1 diabetes mellitus (T1DM), a chronic autoimmune disease that results in complete insulin insufficiency and metabolic dysfunction. According to a survival study that used p ... -
Immunoinformatic Based Designing of Immune Boosting and Non-allergenic Multi-epitope Subunit Vaccine Against the Enterovirus D68
( Bentham Science Publishers , 2025 , Article)Introduction: Enterovirus D68 (EV-D68) is a non-enveloped, positive-sense, single-stranded RNA virus known for causing severe respiratory illnesses and its association with acute flaccid myelitis (AFM) in children. Despite ... -
Association between exposure to polycyclic aromatic hydrocarbons and reproductive health outcomes: a systematic review and meta-analysis
( Springer Nature , 2025 , Article)Background: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants with known harmful effects on human health. However, their specific impact on reproductive outcomes, both cancer-related and ... -
Evaluation of Mineral Content in Preterm Human Milk and Infant Formulas in Qatar: Assessing Compliance With Dietary Recommendations and Label Accuracy
( John Wiley and Sons Inc , 2025 , Article)Preterm infants have higher energy and nutrient needs compared to term infants, with human milk recommended as the primary feeding choice and infant formula as the secondary option. This study aimed to evaluate the ... -
Targeting mTOR and Its Associated Signaling to Induce Cell Death in Breast Cancer Stem Cells
( John Wiley and Sons Inc , 2025 , Article)Breast cancer (BC) is a frequently diagnosed neoplasm in women and the second major cause of cancer-related deaths. Many BC patients develop metastasis and advanced tumors, increasing morbidity and mortality. There is ... -
SKP2 E3 ligase in urological malignancies: a critical regulator of the cell cycle and therapeutic target
( Taylor and Francis Ltd. , 2025 , Article Review)SKP2, an E3 ubiquitin ligase component of the SCF complex, plays a critical role in cell cycle regulation by targeting key inhibitors like p27, p21, and p57 for degradation, thereby promoting G1-S transition. Its overexpression ... -
Selective induction of apoptosis in T-cell acute lymphoblastic leukemia by pristimerin through dual PI3K/AKT pathway inhibition and ROS generation
( Elsevier , 2025 , Article)T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by the aberrant activation of survival pathways, particularly the PI3K/AKT axis. Pristimerin (Prist), a naturally occurring ... -
Dysregulation of Aquaporin-3 and Glyceryl Glucoside Restoring Action in Hidradenitis Suppurativa in Vitro Models
( Cellular Physiology and Biochemistry , 2024 , Article)BACKGROUND/AIMS: Aquaporin-3 (AQP3) is an aquaglyceroporin and peroxiporin that plays a crucial role in skin barrier homeostasis. Dysregulated AQP3 expression has been observed in different inflammatory skin conditions. ... -
Near-infrared photobiomodulation therapy on HD10.6 human sensory neurons cell culture
( Springer Nature , 2025 , Article)PURPOSE: We investigated the molecular effects of near-infrared photobiomodulation therapy (PBMT) on HD10.6 human sensory neuron cell cultures. This study explores the utility of PBMT in modulating the functionality of ... -
Screening of medicinal phytocompounds with structure-based approaches to target key hotspot residues in tyrosyl-DNA phosphodiesterase 1: augmenting sensitivity of cancer cells to topoisomerase I inhibitors
( Taylor and Francis Ltd. , 2025 , Article)One of cancer's well-known hallmarks is DNA damage, yet it's intriguing that DNA damage has been explored as a therapeutic strategy against cancer. Tyrosyl-DNA phosphodiesterase 1, involved in DNA repair from topoisomerase ... -
Natural Compounds Targeting Thymic Stromal Lymphopoietin (TSLP): A Promising Therapeutic Strategy for Atopic Dermatitis
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Atopic dermatitis (AD) is a chronic inflammatory skin disease with rising prevalence, marked by eczematous lesions, itching, and a weakened skin barrier often tied to filaggrin gene mutations. This breakdown allows allergen ... -
Farnesyl Diphosphate Synthase Gene Associated with Loss of Bone Mass Density and Alendronate Treatment Failure in Patients with Primary Osteoporosis
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Aminobisphosphonates (NBPs) are the first-choice medication for osteoporosis (OP); NBP treatment aims at increasing bone mineral density (BMD) by inhibiting the activity of farnesyl diphosphate synthase (FDPS) enzyme in ... -
Biosensing circulating MicroRNAs in autoinflammatory skin diseases: Focus on Hidradenitis suppurativa
( Frontiers Media SA , 2024 , Article)MicroRNAs (miRNAs) play a crucial role in the early diagnosis of autoinflammatory diseases, with Hidradenitis Suppurativa (HS) being a notable example. HS, an autoinflammatory skin disease affecting the pilosebaceous unit, ... -
Genetic mutations in pyoderma gangrenosum, hidradenitis suppurativa, and associated autoinflammatory syndromes: Insights into pathogenic mechanisms and shared pathways
( John Wiley and Sons Inc , 2024 , Article)The review article by Takashi K. Satoh1 discusses dermatological conditions such as pyoderma gangrenosum (PG), hidradenitis suppurativa (HS), and related autoinflammatory syndromes including pyogenic arthritis, PG, and ... -
Notch Signaling in Health and Disease
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)The Notch signaling pathway, a vital and evolutionarily conserved regulator of cellular processes, intricately shapes both health and disease. In the realm of health, Notch signaling assumes a pivotal role in the skin ... -
Can telomeric changes orchestrate the development of autoinflammatory skin diseases?
( Edizioni Minerva Medica , 2024 , Article Review)Telomeres, the safeguarding caps at the tips of chromosomes, are pivotal in the aging process of cells and have been linked to skin ailments and inflammatory conditions. Telomeres undergo a gradual reduction in length and ... -
Immunological findings of West Caucasian bat virus in an accidental host
( American Society for Microbiology , 2025 , Article)The Lyssavirus genus includes seventeen viral species able to cause rabies, an acute and almost invariably fatal encephalomyelitis of mammals. Rabies virus (RABV), which represents the type species of the genus, is a ...
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