Browsing Laboratory Animal Research Center by Title
Now showing items 89-96 of 96
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Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents
( Elsevier , 2022 , Article Review)Cancer is one of the leading causes of death and significantly burdens the healthcare system. Due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. The use of natural products as ... -
The effect of acute ophiobolin A treatment on HO-mediated inflammatory processes
( SAGE Publications Ltd , 2017 , Article)Many microbial and plant-derived metabolites contribute to the production of inflammatory mediators and the expression of pro-inflammatory molecules. Ophiobolin A (OPA) is a fungal secondary metabolite produced by Bipolaris ... -
Thiostrepton inhibits growth and induces apoptosis by targeting FoxM1/SKP2/MTH1 axis in B-precursor acute lymphoblastic leukemia cells
( Taylor and Francis Group , 2021 , Article)Forkhead box M1 (FoxM1) is a transcription factor that plays an important role in the etiology of many cancers, however, its role has not been elucidated in B-precursor acute lymphoblastic leukemia (B-pre-ALL). In the ... -
Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk.
( Frontiers Media , 2019 , Article)The ability of epithelial cells to organize through cell-cell adhesion into a functioning epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent cells are made up of tight junctions ... -
Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy
( BioMed Central Ltd , 2023 , Article)Background: The mechanism of tumor immune escape and progression in colorectal cancer (CRC) is widely investigated in-vitro to help understand and identify agents that might play a crucial role in response to treatment and ... -
The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities
( Springer , 2021 , Article Review)Background: Breast cancer (BC), the second most common cause of cancer-related deaths, remains a significant threat to the health and wellness of women worldwide. The tumor microenvironment (TME), comprising cellular ... -
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy.
( Springer Nature , 2021 , Article Review)Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and ... -
Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells.
( BMC , 2021 , Article Review)Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ...