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Gut Microbiota Dysbiosis in Cafeteria Diet Fed Sprague Dawley Rats
(
Scientific Research Publishing
, 2018 , Article)
Diet plays a major role in the body physiology and metabolism. The quantity,
nature and stability of the macronutrients present in the diet have a major impact on the composition of gut microbiota. Gut microbiota plays a ...
A loss-of-function NCSTN mutation associated with familial Dowling Degos disease and hidradenitis suppurativa
(
Wiley
, 2023 , Article)
Dowling Degos disease (DDD) is a rare autosomal dominant genodermatosis characterized by acquired, slowly progressive reticulated pigmented lesions primarily involving flexural skin areas. Mutations in KRT5, POGLUT-1 and ...
SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle
(
Wiley
, 2017 , Article)
Silent mating type information regulation 2 homologue 1 (SIRT1) activity and content increased significantly in overload-induced hypertrophy. SIRT1-mediated signalling through Akt, the endothelial nitric oxide synthase ...
NF-κB Essential MOdulator (NEMO) Is Critical for Thyroid Function
(
American Society for Biochemistry and Molecular Biology
, 2016 , Article)
The I-κB kinase (IKK) subunit NEMO/IKKγ (NEMO) is an adapter molecule that is critical for canonical activation of NF-κB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis ...
ANIMAL MODEL FOR CHILDHOOD OBESITY
(2017 , Poster)
Obesity has been recognized as a global health problem and linked with chronic diseases such as diabetes mellitus, cardiovascular syndromes, musculoskeletal disorders and some cancers. Children exposed to high
carbohydrate, ...
Abrogation of ORF8-IRF3 binding interface with Carbon nanotube derivatives to rescue the host immune system against SARS-CoV-2 by using molecular screening and simulation approaches.
(
BMC
, 2024 , Article)
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to over six million deaths worldwide. In human immune system, the type 1 interferon (IFN) pathway plays a crucial role in fighting viral infections. However, ...
Real-Time PCR Quantification of Metallothionein Gene Expression in Sprague–Dawley Rats Chronically Exposed to Cd
(
American Association for Laboratory Animal Science
, 2012 , Presentation)
Toxicologic impact of Cd leads to multiple human pathologic conditions,
and its effect on humans and animals has been extensively studied.
Physiologic function of metallothionein (MT1) is not completely understood,
but ...
Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents
(
Elsevier
, 2022 , Article Review)
Cancer is one of the leading causes of death and significantly burdens the healthcare system. Due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. The use of natural products as ...
Fc Epsilon RI–Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients
(
MDPI
, 2023 , Article Review)
Atopic dermatitis (AD) is the most common chronic relapsing neuroinflammatory skin disease that is characterized by a complex and multifactorial pathophysiology. It reflects a profound interplay between genetic and ...
In silico-designed antimicrobial peptide targeting MRSA and E. coli with antibacterial and antibiofilm actions
(
Springer Nature
, 2024 , Article)
Antibiotic resistance is a paramount global health issue, with numerous bacterial strains continually fortifying their resistance against diverse antibiotics. This surge in resistance levels primarily stems from the overuse ...