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Effect of psoriasis linked CARMA2sh gene in transgenic animal model
(2018 , Poster)
Background
• CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB, that has a central role in controlling the immune and inflammatory response, cell survival and ...
Effect of CARMA 2sh gene in Mouse embryonic stem (ES) cells
(2017 , Poster)
CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB that have a central role in the control of immune and inflammatory response, and cell survival and proliferation. ...
In Vitro Analysis of Psoriasis Linked CARMA2sh Gene in Keratinocytes and Mouse Embryonic Stem Cells towards Developing a Murine Transgenic Model
(
American Association For Laboratory Animal Science
, 2017 , Poster)
Psoriasis is a debilitating skin disease affecting approximately 23% of
human population. Genome-wide association studies have identified
more than 40 susceptibility loci for psoriasis. CARMA2 proteins play a
major role ...
NF-κB Essential MOdulator (NEMO) Is Critical for Thyroid Function
(
American Society for Biochemistry and Molecular Biology
, 2016 , Article)
The I-κB kinase (IKK) subunit NEMO/IKKγ (NEMO) is an adapter molecule that is critical for canonical activation of NF-κB, a pleiotropic transcription factor controlling immunity, differentiation, cell growth, tumorigenesis ...
Expression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK)
(2016 , Poster)
Psoriasis is a debilitating skin disease affecting approximately 23% of human population. The disease is considered to have key genetic underpinning and genome wide association studies and meta analysis have identified ...
CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship
(
Nature
, 2017 , Article)
The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic ...