Laboratory Animal Research Center: Recent submissions

Now showing items 81-100 of 127

    • miRNAs as novel immunoregulators in cancer 

      Saife N., Lone; Bhat, Ajaz A.; Wani, Nissar A.; Karedath, Thasni; Hashem, Sheema; ... more authors ( Elsevier , 2021 , Article Review)
      The immune system is a well-known vital regulator of tumor growth, and one of the main hallmarks of cancer is evading the immune system. Immune system deregulation can lead to immune surveillance evasion, sustained cancer ...

    • Chemokine-cytokine networks in the head and neck tumor microenvironment 

      Nisar, Sabah; Yousuf, Parvaiz; Masoodi, Tariq; Wani, Nissar A.; Hashem, Sheema; ... more authors ( MDPI , 2021 , Article Review)
      Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a dismal patient prognosis. Despite significant advances in treatment modalities, the five-year survival rate in patients with HNSCC has improved ...

    • Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells. 

      Chauhan, Ravi; Bhat, Ajaz A; Masoodi, Tariq; Bagga, Puneet; Reddy, Ravinder; ... more authors ( BMC , 2021 , Article Review)
      Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ...

    • Cardiac Myosin Binding Protein-C in Sprague Dawley (SD) Rats exposed to Sub-Chronic oral dose of Cadmium Chloride 

      Al-Borshaid, Enjoud Khalifa; Varadharajan, Kavitha; Shanmugakonar, Muralitharan; Al-Naemi, Hamda ( Qatar University Press , 2021 , Poster)
      Cadmium is one of the major environmental pollutants associated with an increment in industrial and urbanization activities. It has health consequences when it reaches the human diet through the soil, water, and plant. ...

    • The effect of acute ophiobolin A treatment on HO-mediated inflammatory processes 

      Posa, Aniko; Szabo, Renata; Szalai, Zita; Kupai, Krisztina; Deim, Zoltan; ... more authors ( SAGE Publications Ltd , 2017 , Article)
      Many microbial and plant-derived metabolites contribute to the production of inflammatory mediators and the expression of pro-inflammatory molecules. Ophiobolin A (OPA) is a fungal secondary metabolite produced by Bipolaris ...

    • Association of genes with phenotype in autism spectrum disorder. 

      Nisar, Sabah; Hashem, Sheema; Bhat, Ajaz A; Syed, Najeeb; Yadav, Santosh; ... more authors ( Impact Journals , 2019 , Article Review)
      Autism spectrum disorder (ASD) is a genetic heterogeneous neurodevelopmental disorder that is characterized by impairments in social interaction and speech development and is accompanied by stereotypical behaviors such as ...

    • Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury 

      Das, Sandra Concepcion; Al-Naemi, Hamda A. ( Scientific Research Publishing , 2019 , Article Review)
      Cadmium is a known environmental pollutant targeting various organs. Often implicated in cadmium toxicology is the formation of reactive oxygen species, overwhelming the free radical scavenging mechanisms and inducing ...

    • Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine. 

      Al-Naemi, Hamda A; Das, Sandra Concepcion ( Springer , 2020 , Article)
      Cadmium (Cd) is a naturally occurring toxic heavy metal with no known essential biological functions. Exposure to Cd increases the risk of cardiovascular disease by disrupting vascular homeostasis at the endothelium. The ...

    • 1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo 

      Rich, Laurie J; Bagga, Puneet; Wilson, Neil E; Schnall, Mitchell D; Detre, John A; ... more authors ( Nature Research , 2020 , Article)
      Quantitative mapping of the in vivo dynamics of cellular metabolism via non-invasive imaging contributes to our understanding of the initiation and progression of diseases associated with dysregulated metabolic processes. ...

    • Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications. 

      Sher, Gulab; Salman, Nadia Aziz; Khan, Abdul Q; Prabhu, Kirti S; Raza, Afsheen; ... more authors ( Elsevier , 2020 , Article Review)
      The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor ...

    • Functional In Vivo Imaging of Tumors. 

      Haris, Mohammad; Nisar, Sabah; Hashem, Sheema; Bhat, Ajaz A; Yadav, Santosh; ... more authors ( Springer , 2020 , Book chapter)
      Noninvasive imaging of functional and molecular changes in cancer has become an indispensable tool for studying cancer in vivo. Targeting the functional and molecular changes in cancer imaging provides a platform for the ...

    • Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder. 

      Nisar, Sabah; Bhat, Ajaz A; Hashem, Sheema; Syed, Najeeb; Yadav, Santosh K; ... more authors ( MDPI , 2020 , Article Review)
      Post-traumatic stress disorder (PTSD) is a highly disabling condition, increasingly recognized as both a disorder of mental health and social burden, but also as an anxiety disorder characterized by fear, stress, and ...

    • Genetics of structural and functional brain changes in autism spectrum disorder. 

      Hashem, Sheema; Nisar, Sabah; Bhat, Ajaz A; Yadav, Santosh Kumar; Azeem, Muhammad Waqar; ... more authors ( Springer Nature , 2020 , Article Review)
      Autism spectrum disorder (ASD) is a neurological and developmental disorder characterized by social impairment and restricted interactive and communicative behaviors. It may occur as an isolated disorder or in the context ...

    • Exploring Dysregulated Signaling Pathways in Cancer. 

      Nisar, Sabah; Hashem, Sheema; Yadav, Santosh K; Muralitharan, Sankavi; Therachiyil, Lubna; ... more authors ( Bentham Science Publishers , 2020 , Article Review)
      Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. Signaling pathways are an important means of communication from the exterior of cell to intracellular ...

    • Brain microstructural changes support cognitive deficits in HIV uninfected children born to HIV infected mothers 

      Santosh K., Yadav; Gupta, Rakesh K.; Hashem, Sheema; Nisar, Sabah; Azeem, Taha; ... more authors ( Elsevier , 2020 , Article)
      IntroductionAntiretroviral therapy (ART) is considered the most effective way to prevent perinatal transmission of human immunodeficiency virus (HIV). However, there is little knowledge about the effect of ART on the brain ...

    • Single-Voxel H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD ) in humans at 7T using a 32-channel volume coil. 

      Bagga, Puneet; Hariharan, Hari; Wilson, Neil E; Beer, Joanne C; Shinohara, Russell T; ... more authors ( Wiley , 2019 , Article)
      Reliable monitoring of tissue nicotinamide adenine dinucleotide (NAD ) concentration may provide insights on its roles in normal and pathological aging. In the present study, we report a H MRS pulse sequence for the in ...

    • Claudin-1, A Double-Edged Sword in Cancer. 

      Bhat, Ajaz A; Syed, Najeeb; Therachiyil, Lubna; Nisar, Sabah; Hashem, Sheema; ... more authors ( MDPI , 2020 , Article Review)
      Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated ...

    • Sugar alcohol provides imaging contrast in cancer detection 

      Bagga P.; Wilson N.; Rich L.; Marincola F.M.; Schnall M.D.; ... more authors ( NLM (Medline) , 2019 , Article)
      Clinical imaging is widely used to detect, characterize and stage cancers in addition to monitoring the therapeutic progress. Magnetic resonance imaging (MRI) aided by contrast agents utilizes the differential relaxivity ...

    • Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance. 

      Bhat, Ajaz A; Younes, Salma N; Raza, Syed Shadab; Zarif, Lubna; Nisar, Sabah; ... more authors ( BMC , 2020 , Article Review)
      Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia ...

    • Novel potentials of the DPP-4 inhibitor sitagliptin against ischemia-reperfusion (I/R) injury in rat ex-vivo heart model 

      Al-Awar A.; Alm?si N.; Szab? R.; Takacs I.; Murlasits Z.; ... more authors ( MDPI AG , 2018 , Article)
      Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of oral anti-diabetic drugs, implicated in pleiotropic secondary cardioprotective effects. The aim of the study was to unveil the unknown and possible cardioprotective ...