Browsing by Author "Elhissi, Abdelbary"
Now showing items 1-20 of 32
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A simple approach to predict the stability of phospholipid vesicles to nebulization without performing aerosolization studies
Subramanian, Sneha; Khan, Iftikhar; Korale, Oshadie; Alhnan, Mohamed Albed; Ahmed, Waqar; Najlah, Mohammad; Taylor, Kevin M.G.; Elhissi, Abdelbary... more authors ... less authors ( Elsevier B.V. , 2016 , Article)Membrane extrusion was investigated for predicting the stability of soya phosphatidylcholine liposomes and surfactosomes (Tween 80-enriched liposomes) to nebulization. Formulations were prepared with or without cholesterol, ... -
Amlexanox-loaded nanoliposomes showing enhanced anti-inflammatory activity in cultured macrophages: A potential formulation for treatment of oral aphthous stomatitis
Abouzid, Afaf; Moustafa, Abdelrhman Y.; Allcock, Natalie; Najlah, Mohammad; Elhissi, Abdelbary; Stanley, Chi Wi; Ahmed, Waqar; Seville, Peter; Crean, StJohn; Forbes, Robert T.; Elsawy, Mohamed A.... more authors ... less authors ( Elsevier , 2023 , Article)Oral aphthous stomatitis is a common disorder treated with the immunomodulatory drug Amlexanox (AMX), that was administered as a mucoadhesive paste (Aphthasol®). This product was discontinued by FDA in 2014 due to the ... -
Carbon nanotubes: Applications in cancer therapy and drug delivery research
Ahmed, Waqar; Elhissi, Abdelbary; Dhanak, Vinod; Subramani, Karthikeyan ( Elsevier , 2018 , Book chapter)Carbon nanotubes (CNTs) are novel nanocarrier systems that have a wide range of applications in science, engineering, and, the environment. Owing to the possible functionalization of CNTs (i.e., surface-engineering of the ... -
Chemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
Dana, Elkhalifa; Rayan, Menatallah; Negmeldin, Ahmed T.; Elhissi, Abdelbary; Khalil, Ashraf ( Elsevier , 2022 , Article Review)Chemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 ... -
Cyclodextrin diethyldithiocarbamate copper ii inclusion complexes: A promising chemotherapeutic delivery system against chemoresistant triple negative breast cancer cell lines
Said Suliman, Ammar; Khoder, Mouhamad; Tolaymat, Ibrahim; Webster, Matt; Alany, Raid G.; Wang, Weiguang; Elhissi, Abdelbary; Najlah, Mohammad... more authors ... less authors ( MDPI AG , 2021 , Article)Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion ... -
Delivery of anticancer molecules using carbon nanotubes
Ahmed, Isma; Javeed, Aneela; Ahmed, Waqar; Phoenix, D. A.; Elhissi, Abdelbary; Jackson, Mark J.... more authors ... less authors ( Springer International Publishing , 2016 , Book chapter)Since their discovery in 1991, carbon nanotubes (CNTs) have emerged as material structures with numerous potential applications with a number of products already in the market place. An exciting application, which is ... -
Design characteristics of inhaler devices used for pulmonary delivery of medical aerosols
Khan, Iftikhar; Yousaf, Sakib; Alhnan, Mohamed Albed; Ahmed, Waqar; Elhissi, Abdelbary; Jackson, Mark J.... more authors ... less authors ( Springer International Publishing , 2016 , Book chapter)For the treatment of respiratory diseases, it is vital to deliver therapeutic doses of drugs to specific regions in the tracheobronchial tree (TBT) of the lung with maximal efficiency and minimal wastage of medication. ... -
Efficient design to fabricate smart Lumefantrine nanocrystals using DENA® particle engineering technology: Characterisation, in vitro and in vivo antimalarial evaluation and assessment of acute and sub-acute toxicity
Syed Muhammad, Hassan Shah; Mukarram Shah, Syed Muhammad; Khan, Shahzeb; Ullah, Farhat; Ali Shah, Syed Wadood; Ghias, Mehreen; Shahid, Muhammad; Smyth, Hugh DC.; Hussain, Zahid; Sohail, Muhammad; Elhissi, Abdelbary; Isreb, Mohammad... more authors ... less authors ( Elsevier , 2020 , Article)Nanocrystalization technologies have a great potential to substantially increase solubility as well as alleviate the erratic bioavailability behaviour of a range of poorly water soluble drugs. The aim of the current study ... -
Enhancement in Oral Absorption of Ceftriaxone by Highly Functionalized Magnetic Iron Oxide Nanoparticles.
Kawish, Muhammad; Elhissi, Abdelbary; jabri, Tooba; Iqbal, Kanwal Muhammad; Zahid, Hina; Shah, Muhammad Raza... more authors ... less authors ( MDPI , 2020 , Article)The present study aims at the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded N'-methacryloylisonicotinohydrazide (MIH)-functionalized magnetic ... -
Fabrication of hesperidin hybrid lecithin-folic acid silver nanoparticles and its evaluation as anti-arthritis formulation in autoimmune arthritic rat model.
Jabri, Tooba; Roome, Talat; Razzak, Anam; Aziz, Sabahat; Imran, Muhammad; Sikandar, Bushra; Elhissi, Abdelbary; Shafiullah,; Aslam, Shazmeen Mohammad; RazaShah, Muhammad... more authors ... less authors ( Elsevier , 2023 , Article)Rheumatoid arthritis (RA) is an immune-mediated inflammatory disease that results in synovitis, cartilage destruction and loss of joint function. The frequent and long-term administration of anti-rheumatic drugs often leads ... -
Fabrication, characterization and optimization of nanostructured lipid carrier formulations using Beclomethasone dipropionate for pulmonary drug delivery via medical nebulizers
Khan, Iftikhar; Hussein, Sozan; Houacine, Chahinez; Khan Sadozai, Sajid; Islam, Yamir; Bnyan, Ruba; Elhissi, Abdelbary; Yousaf, Sakib... more authors ... less authors ( Elsevier , 2021 , Article)Aerosolization is a non-invasive approach in drug delivery for localized and systemic effect. Nanostructured lipid carriers (NLCs) are new generation versatile carriers, which offer protection from degradation and enhance ... -
A Facile and Novel Approach to Manufacture Paclitaxel-Loaded Proliposome Tablet Formulations of Micro or Nano Vesicles for Nebulization
Khan, Iftikhar; Lau, Katie; Bnyan, Ruba; Houacine, Chahinez; Roberts, Matthew; Isreb, Abdullah; Elhissi, Abdelbary; Yousaf, Sakib... more authors ... less authors ( Springer , 2020 , Article)© 2020, The Author(s). Purpose: The aim of this study was to develop novel paclitaxel-loaded proliposome tablet formulations for pulmonary drug delivery. Method: Proliposome powder formulations (i.e. F1 – F27) were prepared ... -
Galactosylated iron oxide nanoparticles for enhancing oral bioavailability of ceftriaxone
Kawish, Muhammad; Jabri, Tooba; Elhissi, Abdelbary; Zahid, Hina; Muhammad Iqbal, Kanwal; Rao, Komal; Gul, Jasra; Abdullah, Muhammad; Shah, Muhammad Raza... more authors ... less authors ( Taylor and Francis Ltd. , 2021 , Article)The current study focuses on the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded lactobionic acid (LBA)-functionalized iron oxide magnetic ... -
Guiding Factors and Surface Modification Strategies for Biomaterials in Pharmaceutical Product Development
Maheshwari, Neha; Kumar Atneriya, Umesh; Tekade, Muktika; Sharma, Mukesh Chandra; Elhissi, Abdelbary; Tekade, Rakesh K.... more authors ... less authors ( Elsevier , 2019 , Book chapter)With the technological advent in the field of drug delivery and medicines, biomaterials become important owing to their properties such as biocompatibility, functionality, and bioactive and bioinert nature. However, the ... -
Impact of dispersion media and carrier type on spray-dried proliposome powder formulations loaded with beclomethasone dipropionate for their pulmonary drug delivery via a next generation impactor
Khan, Iftikhar; Al-Hasani, Ali; Khan, Mohsin H.; Khan, Aamir N.; -Alam, Fakhr-e; Sadozai, Sajid K.; Elhissi, Abdelbary; Khan, Jehanzeb; Yousaf, Sakib... more authors ... less authors ( Public Library of Science , 2023 , Article)Drug delivery via aerosolization for localized and systemic effect is a non-invasive approach to achieving pulmonary targeting. The aim of this study was to prepare spray-dried proliposome (SDP) powder formulations to ... -
Impact of nanosizing on the formation and characteristics of polymethacrylate films: micro- versus nano-suspensions
Yousaf, Sakib Saleem; Isreb, Abdullah; Khan, Iftikhar; Mewsiga, Enosh; Elhissi, Abdelbary; Ahmed, Waqar; Alhnan, Mohamed A.... more authors ... less authors ( Taylor and Francis Ltd. , 2021 , Article)Aqueous-based film coating suspensions are associated with reliance on alkalinising reagents and poor film formation. The impact of particle size in this process and resultant film properties remains unclear. This study ... -
Impact of phospholipids, surfactants and cholesterol selection on the performance of transfersomes vesicles using medical nebulizers for pulmonary drug delivery
Iftikhar, Khan; Needham, Rachel; Yousaf, Sakib; Houacine, Chahinez; Islam, Yamir; Bnyan, Ruba; Sadozai, Sajid Khan; Elrayess, Mohamed A.; Elhissi, Abdelbary... more authors ... less authors ( Elsevier , 2021 , Article)The aim of this study is to formulate and optimize novel transfersome formulations for pulmonary drug delivery. Transfersome formulations (F1 – F18) were prepared by a thin-film method using three phospholipids (Soya ... -
In Vitro and In Vivo Validation of GATA-3 Suppression for Induction of Adipogenesis and Improving Insulin Sensitivity
Al-Jaber, Hend; Mohamed, Nura A.; Govindharajan, Vijay K.; Taha, Samir; John, Jomon; Halim, Sharique; Alser, Maha; Al-Muraikhy, Shamma; Anwardeen, Najeha Rizwana; Agouni, Abdelali; Elhissi, Abdelbary; Al-Naemi, Hamda A.; Al-Mansoori, Layla; Elrayess, Mohamed A.... more authors ... less authors ( MDPI , 2022 , Article)Impaired adipogenesis is associated with the development of insulin resistance and an increased risk of type 2 diabetes (T2D). GATA Binding Protein 3 (GATA3) is implicated in impaired adipogenesis and the onset of insulin ... -
Instrumentation of Flow-Through USP IV Dissolution Apparatus to Assess Poorly Soluble Basic Drug Products: a Technical Note
Paprskarova, Alice; Mozna, Petra; Oga, Enoche F.; Elhissi, Abdelbary; Alhnan, Mohamed A. ( Springer New York LLC , 2016 , Article)Supersaturation and precipitation are common limitations encountered especially with poorly soluble basic drugs. The aims of this work were to explore the pattern of dissolution and precipitation of poorly soluble basic ... -
Introduction to nanotechnology
Subramani, Karthikeyan; Elhissi, Abdelbary; Subbiah, Usha; Ahmed, Waqar ( Elsevier , 2019 , Book chapter)Nanotechnology describes the science and technology related to the control and manipulation of matter and devices on a scale less than 100 nm and involves fields such as applied physics, materials science, chemistry, ...