• Addressing bias in the definition of SARS-CoV-2 reinfection: implications for underestimation 

      Chemaitelly, Hiam; Ayoub, Houssein H.; Tang, Patrick; Yassine, Hadi M.; Al Thani, Asmaa A.; ... more authors ( Frontiers Media , 2024 , Article)
      Introduction: Reinfections are increasingly becoming a feature in the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, accurately defining reinfection poses methodological ...
    • Advances in Huntington’s Disease Biomarkers: A 10-Year Bibliometric Analysis and a Comprehensive Review 

      Aqel, Sarah; Ahmad, Jamil; Saleh, Iman; Fathima, Aseela; Al Thani, Asmaa A.; ... more authors ( MDPI , 2025 , Article Review)
      Neurodegenerative disorders (NDs) cause progressive neuronal loss and are a significant public health concern, with NDs projected to become the second leading global cause of death within two decades. Huntington’s disease ...
    • Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar. 

      Chemaitelly, Hiam; Ayoub, Houssein H; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R; ... more authors ( National Center for Biotechnology Information , 2025 , Article)
      This study investigated the presence of the healthy vaccinee effect-the imbalance in health status between vaccinated and unvaccinated individuals-in two rigorously conducted COVID-19 vaccine effectiveness studies involving ...
    • Association between lifestyle factors and COVID-19: findings from Qatar Biobank 

      Akbar, Zoha; Kunhipurayil, Hasna H.; Saliba, Jessica; Ahmad, Jamil; Al-Mansoori, Layla; ... more authors ( preprints , 2023 , Article)
      Coronavirus Disease 2019 (COVID-19) exhibits a significant variation in presentation of symptoms ranging from mild to severe life-threatening symptoms, including death. COVID-19 infection susceptibility has been linked ...
    • The Association between Lifestyle Factors and COVID-19: Findings from Qatar Biobank. 

      Akbar, Zoha; Kunhipurayil, Hasna H; Saliba, Jessica; Ahmad, Jamil; Al-Mansoori, Layla; ... more authors ( MDPI , 2024 , Article)
      Coronavirus Disease 2019 (COVID-19) manifestations range from mild to severe life-threatening symptoms, including death. COVID-19 susceptibility has been associated with various factors, but studies in Qatar are limited. ...
    • Biomaterials in Traumatic Brain Injury: Perspectives and Challenges 

      Aqel, Sarah; Al-Thani, Najlaa; Haider, Mohammad Z.; Abdelhady, Samar; Al Thani, Asmaa A.; ... more authors ( MDPI , 2023 , Article Review)
      Traumatic brain injury (TBI) is a leading cause of mortality and long-term impairment globally. TBI has a dynamic pathology, encompassing a variety of metabolic and molecular events that occur in two phases: primary and ...
    • BNT162b2 Versus mRNA-1273 Vaccines: Comparative Analysis of Long-Term Protection Against SARS-CoV-2 Infection and Severe COVID-19 in Qatar 

      Chemaitelly, Hiam; Ayoub, Houssein H; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R; ... more authors ( Wiley , 2024 , Article)
      Background: This study provides a head-to-head comparison of the protection provided by the BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2 infection and against severe COVID-19, covering primary series and third ...
    • Chemical Composition, Antioxidant Capacity, and Anticancerous Effects against Human Lung Cancer Cells of a Terpenoid-Rich Fraction of Inula viscosa 

      Seglab, Fatiha; Abou Assali, Mazen; AlYafei, Thoraya; Hassan, Hassan; Pinto, Diana C. G. A.; ... more authors ( MDPI , 2024 , Article)
      Inula viscosa is a widely used plant in traditional Mediterranean and Middle Eastern medicine for various illnesses. I. viscosa has been shown to have anticancer effects against various cancers, but its effects against ...
    • Comparative effectiveness of one versus two doses of COVID-19 vaccines in Qatar: Evidence of converging protection over time 

      Hiam, Chemaitelly; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R.; ... more authors ( Elsevier , 2025 , Article)
      BackgroundSupply constraints during the coronavirus disease 2019 (COVID-19) pandemic led to vaccination strategies that prioritized first-dose coverage. To evaluate the merit of this approach, this study compared the ...
    • Comprehensive analysis of human coronavirus antibody responses in ICU and non-ICU COVID-19 patients reveals IgG3 against SARS-CoV-2 spike protein as a key biomarker of disease severity 

      Ali, Fatma H.; Gentilcore, Giusy; Al-Jighefee, Hadeel T.; Taleb, Sara Ahmad; Hssain, Ali Ait; ... more authors ( Microbiology Society , 2025 , Article)
      Introduction. Pre-existing immunity to human coronaviruses (HCoVs) may shape the immune response in COVID-19 patients. Increasing evidence suggests that immune cross-reactivity between SARS-CoV-2 and other coronaviruses ...
    • A Decade of Discovery of Huntington's Disease Biomarkers: A Comprehensive Review of its Established and Emerging Bi-omarkers 

      Aqel, Sarah; Ahmad, Jamil; Saleh, Iman; Fathima, Aseela; Al Thani, Asmaa A.; ... more authors ( preprints , 2024 , Article Review)
      Neurodegenerative disorders (NDs) lead to progressive neuronal loss in various brain regions and are a significant public health concern, with NDs expected to become the second-leading cause of death globally within the ...
    • Differential protection against SARS-CoV-2 reinfection pre- and post-Omicron 

      Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R.; ... more authors ( Springer Nature , 2025 , Article)
      The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly evolved over short timescales, leading to the emergence of more transmissible variants such as Alpha and Delta1, 2–3. The arrival of the Omicron ...
    • Effectiveness and durability of a fourth dose of ancestral-strain mRNA vaccines against SARS-CoV-2 infection: a nationwide matched cohort study in Qatar 

      Sukik, Layan; Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; ... more authors ( Nature Research , 2025 , Article)
      Concerns about waning immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the emergence of new variants underscore the need for booster doses. Using a matched cohort design, this ...
    • Effectiveness of ChAdOx1 nCoV-19 (Vaxzevria) primary series vaccine against SARS-CoV-2 beta and delta variants: a nationwide study 

      Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R.; ... more authors ( Springer Nature , 2025 , Article)
      Background: This study assessed the real-world effectiveness of the ChAdOx1 nCoV-19 vaccine in adults against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, symptomatic infection, and severe ...
    • Effectiveness of two and three doses of COVID-19 mRNA vaccines against infection, symptoms, and severity in the pre-omicron era: A time-dependent gradient 

      Layan, Sukik; Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; ... more authors ( Elsevier , 2024 , Article)
      BackgroundVaccines were developed and deployed to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to characterize patterns in the protection provided by the BNT162b2 and ...
    • Estimating SARS-CoV-2 infection incidence and detection rates: Demonstrating a novel surveillance method 

      Ayoub, Houssein H.; Chemaitelly, Hiam; Tang, Patrick; Hasan, Mohammad R.; Yassine, Hadi M.; ... more authors ( Elsevier , 2025 , Article)
      ObjectivesAssessing the cumulative incidence of infection conventionally relies on documented infections or serological surveys, both of which have limitations. This study introduces a novel and practical method leveraging ...
    • Evaluating Hospital Admission Data as Indicators of COVID-19 Severity: A National Assessment in Qatar. 

      Sukik, Layan; Chemaitelly, Hiam; Ayoub, Houssein H; Coyle, Peter; Tang, Patrick; ... more authors ( Oxford University Press , 2025 , Article)
      Accurately assessing SARS-CoV-2 infection severity is essential for understanding the health impact of the infection and evaluating the effectiveness of interventions. This study investigated whether SARS-CoV-2-associated ...
    • History of primary-series and booster vaccination and protection against Omicron reinfection 

      Chemaitelly, Hiam; Ayoub, Houssein H.; Tang, Patrick; Coyle, Peter V.; Yassine, Hadi M.; ... more authors ( American Association for the Advancement of Science , 2023 , Article)
      Laboratory evidence suggests a possibility of immune imprinting for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We investigated the differences in the incidence of SARS-CoV-2 reinfection in a ...
    • Immune histories and natural infection protection during the omicron era 

      Chemaitelly, H. S.; Ayoub, Houssein H.; Bobrovitz, Niklas Jh; Coyle, Peter Valentine; Tang, Patrick K.C.; ... more authors ( Springer Nature , 2025 , Article)
      Background: Past immunological events can either enhance or compromise an individual's future immune protection. This study investigated how different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) natural ...
    • Metabolomics Approaches for the Diagnosis, Treatment, and Better Disease Management of Viral Infections 

      Al-Sulaiti, Haya; Almaliti, Jehad; Naman, C. B.; Al Thani, Asmaa A.; Yassine, Hadi M. ( MDPI , 2023 , Article Review)
      Metabolomics is an analytical approach that involves profiling and comparing the metabolites present in biological samples. This scoping review article offers an overview of current metabolomics approaches and their ...