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المؤلفAl-Sadeq, Duaa W.
المؤلفTaleb, Sara A.
المؤلفZaied, Roan E.
المؤلفFahad, Sara M.
المؤلفSmatti, Maria K.
المؤلفRizeq, Balsam R.
المؤلفAl Thani, Asmaa A.
المؤلفYassine, Hadi M.
المؤلفNasrallah, Gheyath K.
تاريخ الإتاحة2019-05-13T08:57:27Z
تاريخ النشر2019-05-11
اسم المنشورPathogens
المعرّفhttp://dx.doi.org/10.3390/pathogens8020063
الاقتباسAl-Sadeq, D.W.; Taleb, S.A.; Zaied, R.E.; Fahad, S.M.; Smatti, M.K.; Rizeq, B.R.; Al Thani, A.A.; Yassine, H.M.; Nasrallah, G.K. Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update. Pathogens 2019, 8, 63.
الرقم المعياري الدولي للكتاب2076-0817
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11536
الملخصHepatitis B virus (HBV) is an enveloped partial double-stranded DNA virus that can cause acute and chronic hepatitis. According to the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC), 257 million people are living with HBV. Moreover, 20,900 acute hepatitis B cases were reported in 2016. Hepatitis B is highly prevalent in the African, Western Pacific, Eastern Mediterranean, South-East Asia, and European regions, respectively. Due to the high mutational rate of HBV and lack of reverse transcriptase proofreading activity, ten different genotypes with different geographical distributions have been identified. HBV pathogenesis and severity of infection depend on several host and viral factors, particularly, the genetic variability of both the host and virus. Although HBV infection is a global health concern, there is a lack of adequate studies and reports in the Middle East and North Africa (MENA) region. Here, we provide a review on HBV epidemiology, pathogenesis, host–pathogen interactions, coinfection with selected viruses, and laboratory diagnosis, focusing on studies conducted in the MENA region to determine the current situation of the HBV infection and outline the future study areas.
اللغةen
الناشرMDPI
الموضوعHBV
seroprevalence
genotypes
pathogenesis
transfusion
viremia
العنوانHepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update
النوعArticle
رقم العدد63
رقم المجلد8
ESSN2076-0817
dc.accessType Open Access


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