Biomedical Sciences
Recent Submissions
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Intranasal CD40-targeted recombinant MERS-CoV S1 protein is superior to intramuscular immunization in eliciting systemic and mucosal immune responses in mice
( Elsevier , 2026 , Article)The Middle East respiratory syndrome coronavirus (MERS-CoV) is a global One Health challenge with a potential pandemic threat, with no approved vaccines or antiviral drugs available to date. Thus, there is an urgent need ... -
ANTI-CANCEROUS POTENTIAL OF EXTRACTS OF QATARI PLANTS AGAINST A549 LUNG CANCER CELLS AND IDENTIFICATION OF THEIR BIOACTIVE COMPOUNDS UREP30-002-3-002 (BH - 250026)
( QRDI Council , 2025 , Conference)• Lung cancer is the leading cause of cancer deaths worldwide, with NSCLC accounting for most cases. • In Qatar, incidence is rising, driven by tobacco use and late-stage diagnosis. • Current therapies face major limitations, ... -
Thymol's Nanoencapsulation Reduces its Toxicity in Human Cells and Zebrafish Embryos
( Saudi Pharmacy Association (SPS)- Ministry of Health , 2025 , Conference)Thymol, a monoterpenoid and a major bioactive constituent of essential oils (EOs) derived from the plants of Lamiacea family such as Thyme, garnered wider research interest for its diverse biological activity and industrial ... -
PBA 23: Nanoencapsulation of Thymol Mitigates its Toxicity in Cells and Zebrafish Embryos
( College of Education, Qatar University , 2025 , Conference)Thymol, a monoterpenoid and a major boactive constituent of essential oils (EOs) derived from the plants of Lamiacea species such as Thyme, has garnered wider research interest for its diverse pharmaceutical, food, and ... -
Therapeutic Insights into Rubus ulmifolius Schott Leaf Extract: In Vitro Antifungal, Enzyme Inhibition, and Anticancer Activities Integrated with Network Pharmacology and Molecular Docking Analyses of Colorectal and Ovarian Cancer
( MDPI , 2025 , Article)Background/Objectives: This study evaluated the antifungal, enzyme inhibitory, and anticancer properties of the ethyl acetate (EtOAc) leaves extract of Rubus ulmifolius Schott using in vitro assays and in silico analysis. ... -
Edaravone: Advances on cytoprotective effects, pharmacological properties, and mechanisms of action
( Elsevier , 2025 , Article Review)Neurological diseases often lead to life-altering consequences, underscoring the urgent need for therapies that can reverse or mitigate their effects. Effective management of neurological disorders necessitates a thorough ... -
Nanoencapsulation mitigates the toxicity of thymol in human cells and zebrafish embryos
( Taylor and Francis Group , 2025 , Article)This study evaluated the cytotoxicity of free thymol (FT) and thymol encapsulated in monolayer (MNCT) and layer-by-layer nanocapsules (LNCT) in normal human (MCF10A, HaCaT, HdFn), and cancer cell lines (MDA-MB-231, A549, ... -
Bariatric metabolic surgery and cancer risk: Target trial emulation using iterative time distribution matching.
( The Association of Basic Medical Sciences , 2025 , Article)Bariatric metabolic surgery (BMS) is a common intervention for severe obesity, yet its effects on cancer risk remain unclear. Observational studies and meta-analyses yield inconsistent findings, while randomized controlled ... -
Afucosylated IgG Promote Thrombosis in Mouse Injected with SARS-CoV-2 Spike Expressing Megakaryocytes
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Despite the prevalence of fucosylated IgG in plasma, specific IgGs with low core fucosylation sporadically emerge in response to virus infections and blood cell alloantigens. This low fucosylation of IgG is implicated in ... -
Advancing targeted therapy for colorectal cancer: harnessing ligand-directed enzyme prodrug therapy for highly specific interventions
( Frontiers Media SA , 2025 , Article)Colorectal cancer (CRC) is a significant global health burden, ranking as the third most frequently diagnosed cancer and a leading cause of cancer-related mortality. Current therapeutic modalities face challenges in advanced ... -
Parental knowledge and attitudes toward genetic counseling and childhood genetic testing for congenital anomalies in Qatar
( Wiley , 2025 , Article)This study aims to evaluate parental knowledge and attitudes toward genetic counseling and testing in the context of pediatric plastic surgery in Qatar. It assesses baseline knowledge to identify educational gaps and factors ... -
Femoral bone mineral density reference values by sex and ethnicity: Findings from the Qatar Biobank study.
( Elsevier , 2025 , Article)Low bone mineral density (BMD) is a major global health concern due to fracture-related morbidity and mortality. BMD is currently assessed by dual-energy X-ray absorptiometry (DXA) against a US reference population. The ... -
Effectiveness of ChAdOx1 nCoV-19 (Vaxzevria) primary series vaccine against SARS-CoV-2 beta and delta variants: a nationwide study
( Springer Nature , 2025 , Article)Background: This study assessed the real-world effectiveness of the ChAdOx1 nCoV-19 vaccine in adults against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, symptomatic infection, and severe ... -
Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar.
( National Center for Biotechnology Information , 2025 , Article)This study investigated the presence of the healthy vaccinee effect-the imbalance in health status between vaccinated and unvaccinated individuals-in two rigorously conducted COVID-19 vaccine effectiveness studies involving ... -
Second-hand smoke exposure level in the household increases risk of chest pain and wheezing: evidence from Qatar biobank
( Elsevier , 2025 , Article)Background: Despite research on the association between second-hand smoke exposure and chest pain/wheezing, evidence on the levels of exposure in the household and their relation to these outcomes is lacking. Our study ... -
Somatic mutations in Middle East and North Africa breast cancer patients: A systematic review
( Oxford University Press , 2025 , Article)Background Breast cancer presents with distinct clinical and molecular characteristics in the Middle East and North Africa (MENA) region, where women are diagnosed at younger ages and with more aggressive disease compared ... -
Artificial Intelligence in Biomedical Sciences: A Scoping Review
( Frontiers , 2025 , Article)Background: Artificial intelligence (AI) is increasingly playing important roles in healthcare diagnosis, treatment, monitoring, and prevention of diseases. Despite this widespread implementation of AI in biomedical sciences, ... -
Natural Antioxidants as Regulators of Circular RNA Expression and Function
( Wiley , 2025 , Article)Circular RNAs (circRNAs) are a class of noncoding RNAs characterized by covalently closed loop structures that confer high stability and diverse regulatory functions. Emerging evidence suggests that circRNAs modulate gene ... -
Qatar’s National Expanded Metabolic Newborn Screening Program: Incidence and Outcomes
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Newborn screening is an essential public health strategy that aims to detect a range of conditions, including inborn errors of metabolism, in neonates shortly after birth. The timely identification is crucial ... -
Transcriptomic profiling and bioinformatics-driven statistical prioritization of CRC biomarkers: A step toward precision oncology
( Elsevier , 2025 , Article)BackgroundColorectal adenocarcinoma (COAD) is among the most common causes of cancer-related death globally. Early detection and targeted therapy depend on identifying key molecular biomarkers that drive tumor progression. ...
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