Biomedical Sciences
Recent Submissions
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Pharmacometabolomics of sulfonylureas in patients with type 2 diabetes: a cross-sectional study
( Frontiers Media SA , 2024 , Article)Background: Sulfonylureas have been a longstanding pharmacotherapy in the management of type 2 diabetes, with potential benefits beyond glycemic control. Although sulfonylureas are effective, interindividual variability ... -
BNT162b2 Versus mRNA-1273 Vaccines: Comparative Analysis of Long-Term Protection Against SARS-CoV-2 Infection and Severe COVID-19 in Qatar
( Wiley , 2024 , Article)Background: This study provides a head-to-head comparison of the protection provided by the BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2 infection and against severe COVID-19, covering primary series and third ... -
Precision medicine activities and opportunities for shaping maternal and neonatal health in Qatar
( Taylor and Francis Group , 2024 , Article Review)Precision Medicine (PM) is a transformative clinical medicine strategy that aims to revolutionize healthcare by leveraging biological information and biomarkers. In the context of maternal and neonatal health, PM enables ... -
Maternal and neonatal risks and outcomes after bariatric surgery: a comparative population based study across BMI categories in Qatar.
( Springer Nature , 2024 , Article)The impact of Bariatric Surgery (BS) on maternal and neonatal outcomes among pregnant women is not fully understood, especially in comparison to different weight categories. The primary aim of this study is to assess the ... -
The effect of titanium surface treatment by application of constant potential or current on the viability of pre-osteoblast cells: an in-vitro study
( Frontiers Media , 2024 , Article)Objectives: The aim of this study was to investigate the impact of electrochemical treatment of a titanium surface employing constant current and potential on the viability of the tissue cells attached to the surface and ... -
Evaluation of the mindray CL900i CLIA HIV Ag/Ab combo assay for sensitive and specific HIV screening compared to established methods.
( Springer Nature , 2024 , Article)Architect-HIV Ag/Ab combo chemiluminescence assay is globally recognized for its sensitivity but has a notable false-positive rate. In this study, we aim to evaluate the performance of a new cost-effective screening ... -
Alterations in Choline Metabolism in Non-Obese Individuals with Insulin Resistance and Type 2 Diabetes Mellitus
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The prevalence of non-obese individuals with insulin resistance (IR) and type 2 diabetes (T2D) is increasing worldwide. This study investigates the metabolic signature of phospholipid-associated metabolites in non-obese ... -
Identification of KSR2 Variants in Pediatric Patients with Severe Early-Onset Obesity from Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The kinase suppressor of Ras 2 (KSR2) gene is associated with monogenic obesity, and loss-of-function variants in KSR2 have been identified in individuals with severe early-onset obesity. This study investigated KSR2 ... -
Isolated diaphragmatic hydatid cyst: a rare entity in the paediatric population
( Oxford University Press , 2024 , Article)Isolated primary diaphragmatic hydatid disease (HD) occurs in approximately 1% of adult cases. However, this unique presentation of a pediatric diaphragmatic cystic mass has not been previously described in the literature. ... -
Network Pharmacology Integrated With Quantum-Polarized Ligand Docking and Molecular Simulation Revealed the Anti-Diabetic Potential of Curcumin
( Wiley , 2024 , Article)Diabetes mellitus is a chronic metabolic disorder affecting millions of people worldwide and causes serious complications such as diabetic nephropathy. Curcumin, a natural polyphenol derived from turmeric, has demonstrated ... -
Exploring the Dynamic Interplay of Deleterious Variants on the RAF1–RAP1A Binding in Cancer: Conformational Analysis, Binding Free Energy, and Essential Dynamics
( Wiley , 2024 , Article)The RAF1–RAP1A interaction activates the MAPK/ERK pathway which is very crucial in the carcinogenesis process. This protein complex influences tumor formation, proliferation, and metastasis. Understanding aberrant interactions ... -
Exploring the role of exosomes in the pathogenesis and treatment of cardiomyopathies: A comprehensive literature review
( Elsevier , 2024 , Article)Exosomes, a subset of small extracellular vesicles that play a crucial role in intercellular communication, have garnered significant attention for their potential applications in the diagnosis and treatment of cardiomyopathies. ... -
Application of proteomics for novel drug discovery and risk prediction optimisation in stroke and myocardial infarction: a review of in-human studies.
( Elsevier Ltd , 2024 , Article)The use of proteomics in human studies investigating stroke and myocardial infarction (MI) has been increasing, prompting a review of the literature. This revealed proteinaceous biomarkers of stroke from thrombi, brain ... -
Depressed "ping pong" skull fractures in the newborns: A cohort study.
( Wiley online library , 2024 , Report)A ping pong fracture is a rare depressed skull fracture (DSF) observed in infants. It occurs due to the inward buckling of the calvarium, creating a cup-like shape. Trauma during childbirth, particularly from instrumental ... -
Novel Mutations in AKT1 Gene in Prostate Cancer Patients in Jordan
( MDPI , 2024 , Article)The AKT1 oncogene is related to various cancers due to its critical role in the PIC3CA/AKT1 pathway; however, most of the studies screened the hotspot mutation AKT1 (E17K) with various incidences. Low frequency or lack of ... -
Senolytics in diseases: killing to survive
( Elsevier , 2023 , Book chapter)Since the discovery of cellular senescence in 1961, numerous studies have investigated the role of senescent cells in the pathogenesis of many chronic diseases. Cellular senescence, defined by irreversible cell cycle arrest, ... -
Seroprevalence of Toxoplasma gondii and Associated Risk Factors among Pregnant Women in Algeria
( American Society of Tropical Medicine and Hygiene , 2024 , Article)Toxoplasma gondii is an obligate intracellular protozoan parasite affecting all warm-blooded vertebrates, including humans. Infections in humans can lead to severe clinical manifestations in pregnant women and immunocompromised ... -
Transcriptomic analysis reveals zinc-mediated virulence and pathogenicity in multidrug-resistant Acinetobacter baumannii
( Elsevier , 2024 , Article)Acinetobacter baumannii is a gram-negative bacterium well known for its multidrug resistance and connection to nosocomial infections under ESKAPE pathogens. This opportunistic pathogen is ubiquitously associated with ... -
Decoding genetic and pathophysiological mechanisms in amyotrophic lateral sclerosis and primary lateral sclerosis: A comparative study of differentially expressed genes and implicated pathways in motor neuron disorders
( Elsevier , 2024 , Article)Motor Neuron Disorders (MNDs), characterized by the degradation and loss of function of motor neurons, are recognized as fatal conditions with limited treatment options and no known cure. The present study aimed to identify ... -
Revolutionizing Cardiovascular Health with Nano Encapsulated Omega-3 Fatty Acids: A Nano-Solution Approach
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) offer diverse health benefits, such as supporting cardiovascular health, improving cognitive function, promoting joint and musculoskeletal health, and contributing to healthy ...
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