عرض بسيط للتسجيلة

المؤلفPasha, Mazhar
المؤلفSivaraman, Siveen K
المؤلفFrantz, Ronald
المؤلفAgouni, Abdelali
المؤلفMunusamy, Shankar
تاريخ الإتاحة2019-05-23T07:08:44Z
تاريخ النشر2019-03-22
اسم المنشورBiomolecules
المعرّفhttp://dx.doi.org/10.3390/biom9030113
الاقتباسPasha, M.; Sivaraman, S.K.; Frantz, R.; Agouni, A.; Munusamy, S. Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines. Biomolecules 2019, 9, 113.
الرقم المعياري الدولي للكتاب2218-273X
المعرّف113
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11610
الملخصClear cell renal cell carcinoma (ccRCC) is the most common and lethal form of urological cancer diagnosed globally. Mutations of the von Hippel-Lindau tumor-suppressor gene and the resultant overexpression of hypoxia-inducible factor (HIF)-1α protein are considered hallmarks of ccRCC. Persistently activated HIF-1α is associated with increased cell proliferation, angiogenesis, and epithelial⁻mesenchymal transition (EMT), consequently leading to ccRCC progression and metastasis to other organs. However, the status alone cannot predict the differential sensitivity of ccRCC to cancer treatments, which suggests that other molecular differences may contribute to the differential response of ccRCC cells to drug therapies. In this study, we investigated the response to metformin (an antidiabetic drug) of two human ccRCC cell lines Caki-1 and Caki-2, which express wild-type . Our findings demonstrate a differential response between the two ccRCC cell lines studied, with Caki-2 cells being more sensitive to metformin compared to Caki-1 cells, which could be linked to the differential expression of HIF-1 despite both cell lines carrying a wild-type . Our study unveils the therapeutic potential of metformin to inhibit the progression of ccRCC in vitro. Additional preclinical and clinical studies are required to ascertain the therapeutic efficacy of metformin against ccRCC.
راعي المشروعQatar University grants QUUG-CPH\2017-2 and QUCG-CPH-2018\2019-2
اللغةen
الناشرMDPI
الموضوعAMP-activated kinase
hypoxia-inducible factor
metformin
renal cell carcinoma
von Hippel-Lindau
العنوانMetformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines.
النوعArticle
رقم العدد3
رقم المجلد9
ESSN2218-273X
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة