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AuthorPasha, Mazhar
AuthorSivaraman, Siveen K
AuthorFrantz, Ronald
AuthorAgouni, Abdelali
AuthorMunusamy, Shankar
Available date2019-05-23T07:08:44Z
Publication Date2019-03-22
Publication NameBiomolecules
Identifierhttp://dx.doi.org/10.3390/biom9030113
CitationPasha, M.; Sivaraman, S.K.; Frantz, R.; Agouni, A.; Munusamy, S. Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines. Biomolecules 2019, 9, 113.
ISSN2218-273X
Identifier113
URIhttp://hdl.handle.net/10576/11610
AbstractClear cell renal cell carcinoma (ccRCC) is the most common and lethal form of urological cancer diagnosed globally. Mutations of the von Hippel-Lindau tumor-suppressor gene and the resultant overexpression of hypoxia-inducible factor (HIF)-1α protein are considered hallmarks of ccRCC. Persistently activated HIF-1α is associated with increased cell proliferation, angiogenesis, and epithelial⁻mesenchymal transition (EMT), consequently leading to ccRCC progression and metastasis to other organs. However, the status alone cannot predict the differential sensitivity of ccRCC to cancer treatments, which suggests that other molecular differences may contribute to the differential response of ccRCC cells to drug therapies. In this study, we investigated the response to metformin (an antidiabetic drug) of two human ccRCC cell lines Caki-1 and Caki-2, which express wild-type . Our findings demonstrate a differential response between the two ccRCC cell lines studied, with Caki-2 cells being more sensitive to metformin compared to Caki-1 cells, which could be linked to the differential expression of HIF-1 despite both cell lines carrying a wild-type . Our study unveils the therapeutic potential of metformin to inhibit the progression of ccRCC in vitro. Additional preclinical and clinical studies are required to ascertain the therapeutic efficacy of metformin against ccRCC.
SponsorQatar University grants QUUG-CPH\2017-2 and QUCG-CPH-2018\2019-2
Languageen
PublisherMDPI
SubjectAMP-activated kinase
hypoxia-inducible factor
metformin
renal cell carcinoma
von Hippel-Lindau
TitleMetformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines.
TypeArticle
Issue Number3
Volume Number9
ESSN2218-273X
dc.accessType Open Access


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