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المؤلفSiveen, Kodappully S
المؤلفRaza, Afsheen
المؤلفAhmed, Eiman I
المؤلفKhan, Abdul Q
المؤلفPrabhu, Kirti S
المؤلفKuttikrishnan, Shilpa
المؤلفMateo, Jericha M
المؤلفZayed, Hatem
المؤلفRasul, Kakil
المؤلفAzizi, Fouad
المؤلفDermime, Said
المؤلفSteinhoff, Martin
المؤلفUddin, Shahab
تاريخ الإتاحة2019-06-11T09:56:57Z
تاريخ النشر2019-05-01
اسم المنشورCancers
المعرّفhttp://dx.doi.org/10.3390/cancers11060746
الاقتباسSiveen, K.S.; Raza, A.; Ahmed, E.I.; Khan, A.Q.; Prabhu, K.S.; Kuttikrishnan, S.; Mateo, J.M.; Zayed, H.; Rasul, K.; Azizi, F.; Dermime, S.; Steinhoff, M.; Uddin, S. The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer. Cancers 2019, 11, 746.
الرقم المعياري الدولي للكتاب2072-6694
المعرّفArticle Number : 746
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11623
الملخصColorectal cancer (CRC) is one of the most common cancers worldwide, with high morbidity and mortality rates. A number of factors including modulation of the tumor microenvironment, high metastatic capability, and resistance to treatment have been associated with CRC disease progression. Recent studies have documented that tumor-derived extracellular vesicles (EVs) play a significant role in intercellular communication in CRC via transfer of cargo lipids, proteins, DNA and RNAs to the recipient tumor cells. This transfer influences a number of immune-related pathways leading to activation/differentiation/expression of immune cells and modulation of the tumor microenvironment that plays a significant role in CRC progression, metastasis, and drug resistance. Furthermore, tumor-derived EVs are secreted in large amounts in biological fluids of CRC patients and as such the expression analysis of EV cargoes have been associated with prognosis or response to therapy and may be a source of therapeutic targets. This review aims to provide a comprehensive insight into the role of EVs in the modulation of the tumor microenvironment and its effects on CRC progression, metastasis, and drug resistance. On the other hand, the potential role of CRC derived EVs as a source of biomarkers of response and therapeutic targets will be discussed in detail to understand the dynamic role of EVs in CRC diagnosis, treatment, and management.
اللغةen
الناشرMDPI
الموضوعbiomarker
colorectal cancer
drug resistance
extracellular vesicles
metastasis
miRNA
tumor microenvironment
العنوانThe Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer.
النوعArticle
رقم العدد6
رقم المجلد11
dc.accessType Open Access


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