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AuthorHussein, Nozad
AuthorOmer, Huner
AuthorIsmael, Ava
AuthorAlhnan, Mohamed
AuthorElhissi, Abdelbary
AuthorAhmed, Waqar
Available date2019-07-23T08:49:18Z
Publication Date2019-01-01
Publication NamePharmaceutical Development and Technology
Identifierhttp://dx.doi.org/10.1080/10837450.2019.1567762
CitationNozad Hussein, Huner Omer, Ava Ismael, Mohamed Albed Alhnan, Abdelbary Elhissi & Waqar Ahmed (2019): Spray-Dried Alginate Microparticles for Potential Intranasal Delivery of Ropinirole Hydrochloride: Development, Characterization and Histopathological Evaluation, Pharmaceutical Development and Technology, DOI: 10.1080/10837450.2019.1567762
ISSN1083-7450
URIhttp://hdl.handle.net/10576/11646
AbstractRopinirole hydrochloride (RH) is an anti-Parkinson drug with relativity low oral bioavailability owing to its extensive hepatic first pass metabolism. Spray-dried mucoadhesive alginate microspheres of RH were developed and characterized followed by histopathological evaluation using nasal tissue isolated from sheep. Spherical microparticles having high product yield (around 70%) were obtained when the inlet temperature of spray drying was 140 °C. Fourier Transform Infrared (FTIR) studies revealed the compatibility of the drug with the polymer, and scanning electron microscopy (SEM) showed that drug-loaded microparticles were spherical, and the apparent surface roughness was inversely related to the ratio of polymer to drug. Furthermore, size of the spray-dried particles were in the range of 2.5 - 4.37 µm, depending on formulation. All formulations had high drug encapsulation efficiencies (101 - 106%). Drug loaded into the polymeric particles was in the amorphous state and drug molecules were molecularly dispersed in the polymeric matrix of the microparticles which were revealed by X-ray diffraction and differential scanning calorimetry (DSC), respectively. The in vitro drug release was influenced by polymer concentration. Histopathological study demonstrated that RH-loaded sodium alginate microparticles was safe to nasal epithelium. In conclusion, spray drying of RH using sodium alginate polymer has produced microparticles of suitable characteristics for potential intranasal administration.
SponsorIraqi government and Qatar University
Languageen
PublisherTaylor & Francis
SubjectPharmaceutics
nose
brain
delivery
microparticles
TitleSpray-Dried Alginate Microparticles for Potential Intranasal Delivery of Ropinirole Hydrochloride: Development, Characterization and Histopathological Evaluation
TypeArticle
ESSN1097-9867
dc.accessType Open Access


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