Targeting triple negative breast cancer heterogeneity with chalcones: a molecular insight.
| Author | Elkhalifa, Dana |
| Author | Alali, Feras |
| Author | Al Moustafa, Ala-Eddin |
| Author | Khalil, Ashraf |
| Available date | 2019-10-16T06:09:36Z |
| Publication Date | 2019-09-01 |
| Publication Name | Journal of Drug Targeting |
| Identifier | http://dx.doi.org/10.1080/1061186X.2018.1561889 |
| Citation | Steven Rhodes, Spencer Short, Sidhika Sharma, Ramneet Kaur, Mukund Jha. (2019) One-pot mild and efficient synthesis of [1,3]thiazino[3,2- a ]indol-4-ones and their anti-proliferative activity. Organic & Biomolecular Chemistry 17:16, pages 3914-3920 |
| ISSN | 1061-186X |
| Abstract | Triple negative breast cancers (TNBCs) are aggressive heterogeneous cancers with not yet determined conventional targeted medication. Therefore, identification of new alternatives or improved treatment options to combat this deadly disease is highly needed. On the other hand, various derived products with chalcone scaffold were historically considered excellent candidates for the development of anticancer drugs. Chalcones unique chemical structure and their substantial biological activities in cancer cells make them an extremely attractive target for the treatment of several human carcinomas including TNBCs. This review highlights the promising therapeutic role of chalcones in TNBC management. |
| Language | en |
| Publisher | Informa Healthcare |
| Subject | Chalcone heterogeneity metastasis molecular targets triple negative breast cancer (TNBC) |
| Type | Article Review |
| Pagination | 830-838 |
| Issue Number | 8 |
| Volume Number | 27 |
| ESSN | 1029-2330 |
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