Biomedical Research Center Research
Recent Submissions
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Advancing targeted therapy for colorectal cancer: harnessing ligand-directed enzyme prodrug therapy for highly specific interventions
( Frontiers Media SA , 2025 , Article)Colorectal cancer (CRC) is a significant global health burden, ranking as the third most frequently diagnosed cancer and a leading cause of cancer-related mortality. Current therapeutic modalities face challenges in advanced ... -
Oscillatory Disturbed Flow Enhances Inflammatory and Oxidative Stress Markers in Endothelial Cells
( MDPI , 2025 , Article)Hemodynamics significantly impact the biology of endothelial cells (ECs) lining the blood vessels. ECs are exposed to various hemodynamic forces, particularly frictional shear stress from flowing blood. While physiological ... -
Finite Element Analysis of Self Expanding Transcatheter Aortic Valves reveals Increased Stent contact Pressure is Associated with Higher Conduction Abnormality Risk
( The Royal Society , 2025 , Conference)For transcatheter aortic valve implantation (TAVI), selecting optimal valve size and implantation depth within aortic root is crucial for preventing complications, such as conduction problems and paravalvular leak. ... -
Studying Cardiovascular Mechanobiology in Development and Disease with Zebrafish
( The Royal Society , 2025 , Conference)Zebrafish is a practical vertebrate model to investigate human cardiovascular disorders due to several advantages such as close genetic resemblance, cardiac physiological similarities, low maintenance costs, high throughput ... -
Effectiveness of ChAdOx1 nCoV-19 (Vaxzevria) primary series vaccine against SARS-CoV-2 beta and delta variants: a nationwide study
( Springer Nature , 2025 , Article)Background: This study assessed the real-world effectiveness of the ChAdOx1 nCoV-19 vaccine in adults against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, symptomatic infection, and severe ... -
Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar.
( National Center for Biotechnology Information , 2025 , Article)This study investigated the presence of the healthy vaccinee effect-the imbalance in health status between vaccinated and unvaccinated individuals-in two rigorously conducted COVID-19 vaccine effectiveness studies involving ... -
Tyrosine kinase inhibitors and their promising role in treating diabetic retinopathy and other retinal vascular diseases: overview of their routes of administration, pharmacokinetics, formulations, and drug delivery applications
( Taylor and Francis , 2025 , Article)Introduction: Tyrosine Kinase Inhibitors (TKIs) are emerging as a promising alternative to protein-based anti-vascular endothelial growth factors (anti-VEGF) in treating diabetic retinopathy (DR) and other retinal vascular ... -
Environmental Amoxicillin Exposure Induces Cardiotoxicity in Zebrafish Embryos: A Comprehensive Assessment of Heart Function and Molecular Responses
( MDPI , 2025 , Article)Background/Objectives. Environmental pollution poses a significant threat to human health, primarily through the degradation of natural ecosystems. Emerging organic contaminants (EOCs), such as pharmaceuticals like ... -
N-Lactoyl Amino Acids: Emerging Biomarkers in Metabolism and Disease
( Wiley , 2025 , Article)N-lactoyl amino acids (Lac-AA) form an emerging class of metabolites that have gained significant attention in recent years due to their ubiquitous presence in different biological systems and potential roles in various ... -
N-lactoyl amino acids are potential biomarkers for insulin resistance and diabetic complications
( Wiley , 2025 , Article)Aims: N-lactoyl amino acids (Lac-AA) are emerging as crucial players in metabolic research, with potential implications for disease mechanisms and therapeutic interventions. This study exploress the role of Lac-AA in insulin ... -
Patients in hospital with confirmed bacterial airway infection are significantly more likely to have a respiratory virus co-infection
( Microbiology Society , 2025 , Article)Introduction. Respiratory viruses are seen as cofactors in bacterial airway infection, often leading to bacterial pneumonia. This study addressed their role in hospitalized patients with bacterial infection confirmed by ... -
Characterization of Flow Structure and Wall Shear Stress in Patient-Specific Abdominal Aortic Aneurysm Phantom Using Particle Image Velocimetry
( American Society of Mechanical Engineers (ASME) , 2025 , Article)Abdominal aortic aneurysm (AAA) is an irreversible dilation of the abdominal aorta that carries a significant risk of rupture if not adequately screened and treated. This condition poses a severe threat, with a mortality ... -
Emerging Insights into Corynebacterium Kroppenstedtii Complex Associated Breast Abscesses: A Retrospective Study
( Taylor and Francis , 2025 , Article)Introduction: Corynebacterium kroppenstedtii complex (CKC), including C. kroppenstedtii, C. parakroppenstedtii, and C. pseudokroppenstedtii, has been implicated in breast abscesses and granulomatous mastitis, presenting ... -
Evaluating indices of insulin resistance and estimating the prevalence of insulin resistance in a large biobank cohort
( Frontiers , 2025 , Article)Introduction: Insulin resistance (IR) is involved in the pathogenesis of various metabolic disorders. Several surrogate indices of IR have been proposed. We assessed the performance of seven clinically relevant indirect ... -
Immune histories and natural infection protection during the omicron era
( Springer Nature , 2025 , Article)Background: Past immunological events can either enhance or compromise an individual's future immune protection. This study investigated how different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) natural ... -
Lipid Subclasses Differentiate Insulin Resistance by Triglyceride-Glucose Index
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Insulin resistance is a key driver of metabolic syndrome and related disorders, yet its underlying metabolic alterations remain incompletely understood. The Triglyceride-Glucose (TyG) index is an emerging, ... -
Machine learning applications in the analysis of sedentary behavior and associated health risks
( Frontiers Media SA , 2025 , Article Review)Background: The rapid advancement of technology has brought numerous benefits to public health but has also contributed to a rise in sedentary lifestyles, linked to various health issues. As prolonged inactivity becomes a ... -
Impact of meteorological factors on transmission of respiratory viruses across all age groups in the hot arid climate in Qatar
( Frontiers Media SA , 2025 , Article)Background: The association between meteorological parameters and viral transmission in temperate and subtropical arid climates is not fully understood. The climate in Qatar reaches extremes of heat and humidity but retains ... -
Insects in agricultural greenhouses: a metagenomic analysis of microbes in Trialeurodes vaporariorum infesting tomato and cucumber crops
( Frontiers Media SA , 2025 , Article)Introduction: With the predicted 9-10 billion world population increase by 2050 and its accompanying need for sustainable food production, and with the harsh climate conditions challenging agriculture and food security in ... -
Intranasal and Pulmonary Lipid Nanoparticles for Gene Delivery: Turning Challenges into Opportunities
( Dove Medical Press Ltd , 2025 , Article Review)Delivery of nano-therapeutics through the nasal route offers a promising approach for several applications, including intranasal conditions, pulmonary delivery, brain targeting, and vaccination. Despite its potential, this ...
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