Incidence of Chronic Myeloid Leukemia: Systematic Review and Meta-analysis

Abstract

Background: To systematically assess and review the global incidence of Chronic Myeloid Leukemia using meta analyses and explore the factors associated with the variation of incidence of CML. Methods: Observational studies reporting CML from the globe were systematically searched in databases including MEDLINE (Ovid) and ProQuest. The author screened the studies and extracted data and assessed the risk of bias. Hoy’s risk of Bias tool was used to assess the biases in individual studies. Results: Seven studies reporting CML Incidence were included. pooled estimate of the CML incidence were 0.92 per 100,000 populations (95% CI: 0.70 – 1.22), Subgroup analysis shows no significant regional variation between Europe vs other country and global estimate. There was no trend when CML plotted over time. Conclusion: Given the pooled estimates vary widely with substantial heterogeneity, larger, well-designed studies especially in region and countries of developing world (Asia and Africa) are warranted to better understand the frequency and burden of CML.