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المؤلفShaito, Abdullah
المؤلفPosadino, Anna Maria
المؤلفYounes, Nadin
المؤلفHasan, Hiba
المؤلفHalabi, Sarah
المؤلفAlhababi, Dalal
المؤلفAl-Mohannadi, Anjud
المؤلفAbdel-Rahman, Wael M
المؤلفEid, Ali H
المؤلفNasrallah, Gheyath K
المؤلفPintus, Gianfranco
تاريخ الإتاحة2020-03-22T09:38:00Z
تاريخ النشر2020-03-01
اسم المنشورInternational Journal of Molecular Sciences
المعرّفhttp://dx.doi.org/10.3390/ijms21062084
الاقتباسShaito, A.; Posadino, A.M.; Younes, N.; Hasan, H.; Halabi, S.; Alhababi, D.; Al-Mohannadi, A.; Abdel-Rahman, W.M.; Eid, A.H.; Nasrallah, G.K.; Pintus, G. Potential Adverse Effects of Resveratrol: A Literature Review. Int. J. Mol. Sci. 2020, 21, 2084.
الرقم المعياري الدولي للكتاب1661-6596
معرّف المصادر الموحدhttp://hdl.handle.net/10576/13477
الملخصDue to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects. In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.
اللغةen
الناشرMDPI
الموضوعanticancer
antioxidant effects
biphasic
oxidative DNA damage
pro-oxidant effects
reactive oxygen species (ROS)
resveratrol
العنوانPotential Adverse Effects of Resveratrol: A Literature Review.
النوعArticle Review
رقم العدد6
رقم المجلد21
ESSN1422-0067
dc.accessType Open Access


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