عرض بسيط للتسجيلة

المؤلفJebaraj Walter, Charles Emmanuel
المؤلفDurairajan, Sankari
المؤلفPeriyandavan, Kalaiselvi
المؤلفPriya Doss C, George
المؤلفDavis G, Dicky John
المؤلفVasanthi A, Hannah Rachel
المؤلفJohnson, Thanka
المؤلفZayed, Hatem
تاريخ الإتاحة2020-04-05T10:08:49Z
تاريخ النشر2020-03-01
اسم المنشورExpert Review of Molecular Diagnostics
المعرّفhttp://dx.doi.org/10.1080/14737159.2020.1743688
الاقتباسCharles Emmanuel Jebaraj Walter, Sankari Durairajan, Kalaiselvi Periyandavan, George Priya Doss C, Dicky John Davis G, Hannah Rachel Vasanthi A, Thanka Johnson & Hatem Zayed (2020) Bladder neoplasms and NF-κB: an unfathomed association, Expert Review of Molecular Diagnostics, DOI: 10.1080/14737159.2020.1743688
الرقم المعياري الدولي للكتاب1473-7159
معرّف المصادر الموحدhttp://hdl.handle.net/10576/13794
الملخصBladder cancer is the second most common genitourinary tract cancer and is often recurrent and/or chemoresistant after tumor resection. Cigarette smoking, exposure to aromatic amines, and chronic infection/inflammation are bladder cancer risk factors. NF-κB is a transcription factor that plays a critical role in normal physiology and bladder cancer. Bladder cancer patients have constitutively active NF-κB triggered by pro-inflammatory cytokines, chemokines, and hypoxia, augmenting carcinogenesis and progression.: NF-κB orchestrates protein interactions (PTEN, survivin, VEGF), regulation (CYLD, USP13) and gene expression (Trp 53) resulting in bladder cancer progression, recurrence and resistance to therapy. This review focuses on NF-κB in bladder inflammation, cancer and resistance to therapy.: NF-κB and bladder cancer necessitate further research to develop better diagnostic and treatment regimens that address progression, recurrence and resistance to therapy. NF-κB is a master regulator that can act with or on minimally one cancer hallmark gene or protein, leading to bladder cancer progression (Tp53, PTEN, VEGF, HMGB1, CYLD, USP13), recurrence (PCNA, BcL-2, JUN) and resistance to therapy (P-gp, twist, SETD6). Thus, an understanding of bladder cancer in relation to NF-κB will offer improved strategies and efficacious targeted therapies resulting in minimal progression, recurrence and resistance to therapy.
اللغةen
الناشرTaylor & Francis
الموضوعBladder cancer
NF-κB
chemoresistance
inflammation
signal transduction
العنوانBladder neoplasms and NF-κB: an unfathomed association.
النوعArticle
ESSN1744-8352
dc.accessType Abstract Only


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة