عرض بسيط للتسجيلة

المؤلفArifulIslam, Mohammad
المؤلفFirdous, Jannatul
المؤلفBadruddoza, Abu Zayed Md
المؤلفReesor, Emma
المؤلفAzad , Mohammad
المؤلفHasan, Anwarul
المؤلفLim, Michael
المؤلفCao, Wuji
المؤلفGuillemette, Simon
المؤلفSuCho, Chong
تاريخ الإتاحة2020-05-15T00:15:02Z
تاريخ النشر2019
اسم المنشورBiomaterials
المصدرScopus
الرقم المعياري الدولي للكتاب1429612
معرّف المصادر الموحدhttp://dx.doi.org/10.1016/j.biomaterials.2018.10.041
معرّف المصادر الموحدhttp://hdl.handle.net/10576/14898
الملخصVaccines are one of the greatest medical interventions of all time and have been successful in controlling and eliminating a myriad of diseases over the past two centuries. Among several vaccination strategies, mucosal vaccines have wide clinical applications and attract considerable interest in research, showing potential as innovative and novel therapeutics. In mucosal vaccination, targeting (microfold) M cells is a frontline prerequisite for inducing effective antigen-specific immunostimulatory effects. In this review, we primarily focus on materials engineered for use as vaccine delivery platforms to target M cells. We also describe potential M cell targeting areas, methods to overcome current challenges and limitations of the field. Furthermore, we present the potential of biomaterials engineering as well as various natural and synthetic delivery technologies to overcome the challenges of M cell targeting, all of which are absent in current literature. Finally, we briefly discuss manufacturing and regulatory processes to bring a robust perspective on the feasibility and potential of this next-generation vaccine technology.
راعي المشروعThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea ( NRF ) funded by the Ministry of Education (No. 2016936920 ) (Cho CS), Qatar National Research Foundation (QNRF) as a part of Qatar Foundation grants NPRP9-144-3-021 and NPRP10-0123-170-222 (Hasan A) and the grant GCC-2017-005 (Hasan A) from Qatar University as part of the GCC research program .
اللغةen
الناشرElsevier Ltd
الموضوعAntibody response
Engineered materials
M cell
Mucosa-associated lymphoid tissues
Mucosal vaccination
Peyer's patch
Targeted delivery systems
العنوانM cell targeting engineered biomaterials for effective vaccination
النوعArticle
الصفحات75-94
رقم المجلد192
dc.accessType Abstract Only


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة