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AuthorArifulIslam, Mohammad
AuthorFirdous, Jannatul
AuthorBadruddoza, Abu Zayed Md
AuthorReesor, Emma
AuthorAzad , Mohammad
AuthorHasan, Anwarul
AuthorLim, Michael
AuthorCao, Wuji
AuthorGuillemette, Simon
AuthorSuCho, Chong
Available date2020-05-15T00:15:02Z
Publication Date2019
Publication NameBiomaterials
ResourceScopus
ISSN1429612
URIhttp://dx.doi.org/10.1016/j.biomaterials.2018.10.041
URIhttp://hdl.handle.net/10576/14898
AbstractVaccines are one of the greatest medical interventions of all time and have been successful in controlling and eliminating a myriad of diseases over the past two centuries. Among several vaccination strategies, mucosal vaccines have wide clinical applications and attract considerable interest in research, showing potential as innovative and novel therapeutics. In mucosal vaccination, targeting (microfold) M cells is a frontline prerequisite for inducing effective antigen-specific immunostimulatory effects. In this review, we primarily focus on materials engineered for use as vaccine delivery platforms to target M cells. We also describe potential M cell targeting areas, methods to overcome current challenges and limitations of the field. Furthermore, we present the potential of biomaterials engineering as well as various natural and synthetic delivery technologies to overcome the challenges of M cell targeting, all of which are absent in current literature. Finally, we briefly discuss manufacturing and regulatory processes to bring a robust perspective on the feasibility and potential of this next-generation vaccine technology.
SponsorThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea ( NRF ) funded by the Ministry of Education (No. 2016936920 ) (Cho CS), Qatar National Research Foundation (QNRF) as a part of Qatar Foundation grants NPRP9-144-3-021 and NPRP10-0123-170-222 (Hasan A) and the grant GCC-2017-005 (Hasan A) from Qatar University as part of the GCC research program .
Languageen
PublisherElsevier Ltd
SubjectAntibody response
Engineered materials
M cell
Mucosa-associated lymphoid tissues
Mucosal vaccination
Peyer's patch
Targeted delivery systems
TitleM cell targeting engineered biomaterials for effective vaccination
TypeArticle
Pagination75-94
Volume Number192
dc.accessType Abstract Only


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