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AuthorHassani, Abdelkader
AuthorMahmood, Syed
AuthorEnezei, Hamid Hammad
AuthorHussain, Siti Aslina
AuthorHamad, Hamad Ali
AuthorAldoghachi, Ahmed Faris
AuthorHagar, Abdullah
AuthorDoolaanea, Abd Almonem
AuthorIbrahim, Wisam Nabeel
Available date2020-06-15T08:56:35Z
Publication Date2020-05-01
Publication NameMolecules
Identifierhttp://dx.doi.org/10.3390/molecules25092244
CitationHassani A, Mahmood S, Enezei HH, et al. Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin. Molecules. 2020;25(9):2244. Published 2020 May 10. doi:10.3390/molecules25092244
ISSN1420-3049
URIhttp://hdl.handle.net/10576/15030
AbstractThe approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared using the ionotropic gelation technique and further subjected to physico-chemical characterization using attenuated total reflectance-Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM). The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was -15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties that might aid in future cancer therapy.
Languageen
PublisherMDPI
Subjectcurcumin
cytotoxicity
gum Arabic
nanoparticles
sodium alginate
TitleFormulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin.
TypeArticle
Issue Number9
Volume Number25
ESSN1420-3049
dc.accessType Open Access


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