Poly(lactic-co-glycolic acid) Nanoparticles Loaded with Callistemon citrinus Phenolics Exhibited Anticancer Properties against Three Breast Cancer Cell Lines
Author | Ahmed, Rashid |
Author | Tariq, Muhammad |
Author | Ahmad, Irfan S. |
Author | Fouly, Hanafy |
Author | Fakhar-I-Abbas |
Author | Hasan, Anwarul |
Author | Kushad, Mosbah |
Available date | 2020-08-18T08:34:46Z |
Publication Date | 2019 |
Publication Name | Journal of Food Quality |
Resource | Scopus |
ISSN | 1469428 |
Abstract | Fruit and vegetable diets rich in phenolic compounds reduce the risk of various cancers and offer multiple other health benefits due to their bioactivity and powerful antioxidant properties. However, the human health benefits of most phenolic compounds are restricted due to their limited aqueous solubility, low absorption, restricted passive cellular efflux, and poor gastrointestinal stability. Nanotechnology has been used to deliver various therapeutic drugs to specific targets overcoming many of the limitations of direct treatments. This study was designed to develop poly(lactic-co-glycolic acid) (PLGA) nanoencapsulated phenolic-rich extracts from Callistemon citrinus and berberine and to evaluate their effectiveness against extremely invasive MDA-MB 231, moderately invasive MCF-10A, and minimally invasive MCF-7 breast cancers. We have achieved about 80% encapsulation of phenolics from C. citrinus. Most encapsulated nanoparticles were polygonal with particles sizes of 200 to 250 nm. Release of phenolics from encapsulation during storage was biphasic during the first week and then levelled off thereafter. Nanoencapsulated phenolics from C. citrinus extract, berberine, and combination of both enhanced their bioactivity against the three breast cancer cell lines by nearly 2-fold. Growth inhibition of cells was a linear curve relative to phenolic concentration, with a maximum inhibition of nearly 100% at 0.1 mg/ml compared to control. Copyright - 2019 Rashid Ahmed et al. This is an open access article distributed under the Creative Commons Attribution License |
Sponsor | Support for this research was provided to RA by the Higher Education Commission (HEC) of Pakistan under International Research Support Initiative Program (IRSIP), M. M. Kushad by the Hatch Fund, and A. Hasan by the Qatar National Research Fund (grant no. NPRP10-0120-170211). �e publication of this article was funded by Qatar National Library. Technical and training support was provided by Dr. Angana Senpan and staff at the Bionanotechnology, Micro and Nanotechnology, Center for Nanoscale Science and Technology, and the Frederick Seitz Materials Research Laboratories at University of Illinois at Urbana/Champaign, IL, USA. |
Language | en |
Publisher | Hindawi Limited |
Subject | Rhodomyrtus Tomentosa Callistemon Viminalis Phloroglucinol |
Type | Article |
Volume Number | 2019 |
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