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المؤلفNisar, Sabah
المؤلفBhat, Ajaz A
المؤلفHashem, Sheema
المؤلفSyed, Najeeb
المؤلفYadav, Santosh K
المؤلفUddin, Shahab
المؤلفFakhro, Khalid
المؤلفBagga, Puneet
المؤلفThompson, Paul
المؤلفReddy, Ravinder
المؤلفFrenneaux, Michael P
المؤلفHaris, Mohammad
تاريخ الإتاحة2020-09-14T09:03:19Z
تاريخ النشر2020-06-01
اسم المنشورInternational Journal of Molecular Sciences
المعرّفhttp://dx.doi.org/10.3390/ijms21124503
الاقتباسNisar, S.; Bhat, A.A.; Hashem, S.; Syed, N.; Yadav, S.K.; Uddin, S.; Fakhro, K.; Bagga, P.; Thompson, P.; Reddy, R.; Frenneaux, M.P.; Haris, M. Genetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder. Int. J. Mol. Sci. 2020, 21, 4503.
الرقم المعياري الدولي للكتاب1661-6596
معرّف المصادر الموحدhttp://hdl.handle.net/10576/16106
الملخصPost-traumatic stress disorder (PTSD) is a highly disabling condition, increasingly recognized as both a disorder of mental health and social burden, but also as an anxiety disorder characterized by fear, stress, and negative alterations in mood. PTSD is associated with structural, metabolic, and molecular changes in several brain regions and the neural circuitry. Brain areas implicated in the traumatic stress response include the amygdala, hippocampus, and prefrontal cortex, which play an essential role in memory function. Abnormalities in these brain areas are hypothesized to underlie symptoms of PTSD and other stress-related psychiatric disorders. Conventional methods of studying PTSD have proven to be insufficient for diagnosis, measurement of treatment efficacy, and monitoring disease progression, and currently, there is no diagnostic biomarker available for PTSD. A deep understanding of cutting-edge neuroimaging genetic approaches is necessary for the development of novel therapeutics and biomarkers to better diagnose and treat the disorder. A current goal is to understand the gene pathways that are associated with PTSD, and how those genes act on the fear/stress circuitry to mediate risk vs. resilience for PTSD. This review article explains the rationale and practical utility of neuroimaging genetics in PTSD and how the resulting information can aid the diagnosis and clinical management of patients with PTSD.
راعي المشروعSidra Medicine funded this research to Mohammad Haris (5071012001) and Ajaz A. Bhat (5011041002).
اللغةen
الناشرMDPI
الموضوعMRI
PET
PTSD
imaging genetics
neuroimaging
العنوانGenetic and Neuroimaging Approaches to Understanding Post-Traumatic Stress Disorder.
النوعArticle Review
رقم العدد12
رقم المجلد21
ESSN1422-0067
dc.accessType Open Access


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