Browsing Laboratory Animal Research Center (Research) by Title
Now showing items 1-20 of 129
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1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo
( Nature Research , 2020 , Article)Quantitative mapping of the in vivo dynamics of cellular metabolism via non-invasive imaging contributes to our understanding of the initiation and progression of diseases associated with dysregulated metabolic processes. ... -
Abrogation of ORF8-IRF3 binding interface with Carbon nanotube derivatives to rescue the host immune system against SARS-CoV-2 by using molecular screening and simulation approaches.
( BMC , 2024 , Article)The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to over six million deaths worldwide. In human immune system, the type 1 interferon (IFN) pathway plays a crucial role in fighting viral infections. However, ... -
Analysis of E2F1 single-nucleotide polymorphisms reveals deleterious non-synonymous substitutions that disrupt E2F1-RB protein interaction in cancer
( Elsevier , 2024 , Article)Cancer is a medical condition that is caused by the abnormal growth and division of cells, leading to the formation of tumors. The E2F1 and RB pathways are critical in regulating cell cycle, and their dysregulation can ... -
Animal Health Monitoring Program (AHMP) of LARC
(2017 , Poster)Animal health monitoring is important to maintain the health of the animals used for research purpose. Maintaining healthy research animals is the prime requisite for best research outcomes. Health monitoring is performed ... -
Animal Husbandry And Care
(2017 , Poster)* Qatar University – Laboratory Animal Research Centre (LARC) is providing highest quality animal husbandry and care * LARC is Specific pathogen Free (SPF) facility with state of the art animal housing & supporting ... -
ANIMAL MODEL FOR CHILDHOOD OBESITY
(2017 , Poster)Obesity has been recognized as a global health problem and linked with chronic diseases such as diabetes mellitus, cardiovascular syndromes, musculoskeletal disorders and some cancers. Children exposed to high carbohydrate, ... -
Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells
( Elsevier , 2022 , Article)Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by ... -
Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)The growing global burden of malignant tumors with increasing incidence and mortality rates underscores the urgent need for more effective and less toxic therapeutic options. Herbal compounds are being increasingly studied ... -
Applications of polydopaminic nanomaterials in mucosal drug delivery
( Elsevier , 2023 , Article Review)Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic ... -
Association between maternal exposure to polycyclic aromatic hydrocarbons and birth anthropometric outcomes: A systematic review and meta-analysis
( Elsevier , 2024 , Article Review)BackgroundPrevious research has proposed that exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy could potentially lead to a higher risk of adverse birth anthropometric outcomes. However, the current ... -
Association of genes with phenotype in autism spectrum disorder.
( Impact Journals , 2019 , Article Review)Autism spectrum disorder (ASD) is a genetic heterogeneous neurodevelopmental disorder that is characterized by impairments in social interaction and speech development and is accompanied by stereotypical behaviors such as ... -
Beyond genetics: Exploring the role of epigenetic alterations in breast cancer
( Elsevier , 2024 , Article Review)Breast cancer remains a major global health challenge. Its rising incidence is attributed to factors such as delayed diagnosis, the complexity of its subtypes, and increasing drug resistance, all contributing to less-than-ideal ... -
Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis
( Frontiers Media S.A. , 2022 , Article)Abnormal expression of Forkhead box protein M1 (FOXM1) and serine/threonine kinase Budding uninhibited by benzimidazoles 1 (BUB1B) contributes to the development and progression of several cancers, including chronic ... -
Biosecurity And Biosafety In LARC
(2017 , Poster)* LARC is Specific Pathogen Free(SPF) facility * LARC is free of Specific list of Pathogens maintained by routine testing. * Bio security & Bio safety are main components to maintain the LARC facility -
Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans
( Springer Nature , 2024 , Article)Non-melanoma skin cancer (NMSC), encompassing basal and squamous cell carcinoma, is the most prevalent cancer in the United States. While surgical removal remains the conventional therapy with a 95% 5-year cure rate, there ... -
Brain microstructural changes support cognitive deficits in HIV uninfected children born to HIV infected mothers
( Elsevier , 2020 , Article)IntroductionAntiretroviral therapy (ART) is considered the most effective way to prevent perinatal transmission of human immunodeficiency virus (HIV). However, there is little knowledge about the effect of ART on the brain ... -
Brain Microstructural Changes Support Cognitive Deficits in Normal Children Born to HIVinfected Mothers
(2018 , Conference)Synopsis In the current study, we evaluated the brain integrity [by mapping the fractional anisotropy (FA) and mean diffusivity (MD)] and neurocognitive performance (NP) in normal children (NCI) born to HIV-infected ... -
Cadmium Toxicity: Oxidative Stress, Inflammation and Tissue Injury
( Scientific Research Publishing , 2019 , Article Review)Cadmium is a known environmental pollutant targeting various organs. Often implicated in cadmium toxicology is the formation of reactive oxygen species, overwhelming the free radical scavenging mechanisms and inducing ... -
Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine.
( Springer , 2020 , Article)Cadmium (Cd) is a naturally occurring toxic heavy metal with no known essential biological functions. Exposure to Cd increases the risk of cardiovascular disease by disrupting vascular homeostasis at the endothelium. The ... -
Cadmium: An Emerging Role in Adipose Tissue Dysfunction
( Springer , 2021 , Article Review)Cadmium (Cd) is a toxic heavy metal that is widespread in the environment due to the substantial anthropogenic inputs from the agriculture and industrial sectors. The toxic impact of Cd adversely affects human health and ...
