Show simple item record

AuthorBagga, Puneet
AuthorHariharan, Hari
AuthorWilson, Neil E
AuthorBeer, Joanne C
AuthorShinohara, Russell T
AuthorElliott, Mark A
AuthorBaur, Joseph A
AuthorMarincola, Francesco M
AuthorWitschey, Walter R
AuthorHaris, Mohammad
AuthorDetre, John A
AuthorReddy, Ravinder
Available date2020-09-14T10:11:53Z
Publication Date2019
Publication NameMagnetic Resonance in Medicine
Identifierhttp://dx.doi.org/10.1002/mrm.27971
CitationBagga, P, Hariharan, H, Wilson, NE, et al. Single‐Voxel 1H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD+) in humans at 7T using a 32‐channel volume coil. Magn Reson Med. 2020; 83: 806– 814. https://doi.org/10.1002/mrm.27971
ISSN0740-3194
URIhttp://hdl.handle.net/10576/16109
AbstractReliable monitoring of tissue nicotinamide adenine dinucleotide (NAD ) concentration may provide insights on its roles in normal and pathological aging. In the present study, we report a H MRS pulse sequence for the in vivo, localized H MRS detection of NAD from the human brain. Studies were carried out on a 7T Siemens MRI scanner using a 32-channel product volume coil. The pulse sequence consisted of a spectrally selective low bandwidth E-BURP-1 90° pulse. PRESS localization was achieved using optimized Shinnar-Le Roux 180° pulses and overlapping gradients were used to minimize the TE. The reproducibility of NAD quantification was measured in 11 healthy volunteers. The association of cerebral NAD with age was assessed in 16 healthy subjects 26-78 years old. Spectra acquired from a voxel placed in subjects' occipital lobe consisted of downfield peaks from the H , H , and H protons of the nicotinamide moiety of NAD between 8.9-9.35 ppm. The mean ± SD within-session and between-session coefficients of variation were found to be 6.14 ± 2.03% and 6.09 ± 3.20%, respectively. In healthy volunteers, an age-dependent decline of the NAD levels in the brain was also observed (β = -1.24 μM/y, SE = 0.21, P < 0.001). We demonstrated the feasibility and robustness of a newly developed H MRS technique to measure localized cerebral NAD at 7T MRI using a commercially available RF head coil. This technique may be further applied to detect and quantify NAD from different regions of the brain as well as from other tissues.
Languageen
PublisherWiley
Subject1H MRS
E-BURP-1
NAD+
aging
brain
TitleSingle-Voxel H MR spectroscopy of cerebral nicotinamide adenine dinucleotide (NAD ) in humans at 7T using a 32-channel volume coil.
TypeArticle
Pagination806-814
Issue Number3
Volume Number83
ESSN1522-2594
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record