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AuthorHashem, Sheema
AuthorNisar, Sabah
AuthorBhat, Ajaz A
AuthorYadav, Santosh Kumar
AuthorAzeem, Muhammad Waqar
AuthorBagga, Puneet
AuthorFakhro, Khalid
AuthorReddy, Ravinder
AuthorFrenneaux, Michael P
AuthorHaris, Mohammad
Available date2020-09-14T10:34:38Z
Publication Date2020-07-13
Publication NameTranslational Psychiatry
Identifierhttp://dx.doi.org/10.1038/s41398-020-00921-3
CitationHashem, S., Nisar, S., Bhat, A.A. et al. Genetics of structural and functional brain changes in autism spectrum disorder. Transl Psychiatry 10, 229 (2020). https://doi.org/10.1038/s41398-020-00921-3
URIhttp://hdl.handle.net/10576/16110
AbstractAutism spectrum disorder (ASD) is a neurological and developmental disorder characterized by social impairment and restricted interactive and communicative behaviors. It may occur as an isolated disorder or in the context of other neurological, psychiatric, developmental, and genetic disorders. Due to rapid developments in genomics and imaging technologies, imaging genetics studies of ASD have evolved in the last few years. Increased risk for ASD diagnosis is found to be related to many specific single-nucleotide polymorphisms, and the study of genetic mechanisms and noninvasive imaging has opened various approaches that can help diagnose ASD at the nascent level. Identifying risk genes related to structural and functional changes in the brain of ASD patients provide a better understanding of the disease's neuropsychiatry and can help identify targets for therapeutic intervention that could be useful for the clinical management of ASD patients.
SponsorThis study was supported by a PI grant from Sidra Medicine (5071012001) to M.H. A.A.B. is supported by Sidra Medicine internal grant (5011041002).
Languageen
PublisherSpringer Nature
SubjectAutism spectrum disorder
HOX genes
CNTNAP2 gene
TitleGenetics of structural and functional brain changes in autism spectrum disorder.
TypeArticle Review
Pagination229
Issue Number1
Volume Number10
ESSN2158-3188
dc.accessType Open Access


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