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AuthorRich, Laurie J
AuthorBagga, Puneet
AuthorWilson, Neil E
AuthorSchnall, Mitchell D
AuthorDetre, John A
AuthorHaris, Mohammad
AuthorReddy, Ravinder
Available date2020-09-14T10:56:22Z
Publication Date2020
Publication NameNature Biomedical Engineering
Identifierhttp://dx.doi.org/10.1038/s41551-019-0499-8
CitationRich, L.J., Bagga, P., Wilson, N.E. et al. 1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo. Nat Biomed Eng 4, 335–342 (2020). https://doi.org/10.1038/s41551-019-0499-8
ISSN2157-846X
URIhttp://hdl.handle.net/10576/16111
AbstractQuantitative mapping of the in vivo dynamics of cellular metabolism via non-invasive imaging contributes to our understanding of the initiation and progression of diseases associated with dysregulated metabolic processes. Current methods for imaging cellular metabolism are limited by low sensitivities, costs or the use of specialized hardware. Here, we introduce a method that captures the turnover of cellular metabolites by quantifying signal reductions in proton magnetic resonance spectroscopy (MRS) resulting from the replacement of H with H. The method, which we termed quantitative exchanged-label turnover MRS, only requires deuterium-labelled glucose and standard magnetic resonance imaging scanners, and with a single acquisition provides steady-state information and metabolic rates for several metabolites. We used the method to monitor glutamate, glutamine, γ-aminobutyric acid and lactate in the brains of unaffected and glioma-bearing rats following the administration of H-labelled glucose and H-labelled acetate. Quantitative exchanged-label turnover MRS should broaden the applications of routine H MRS.
Languageen
PublisherNature Research
SubjectCancer imaging
Cancer metabolism
Magnetic resonance imaging
Neuroscience
Translational research
Title1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo
TypeArticle
Pagination335–342
Volume Number4
dc.accessType Abstract Only


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