Show simple item record

AuthorS, Udhaya Kumar
AuthorRajan, Bithia
AuthorD, Thirumal Kumar
AuthorV, Anu Preethi
AuthorAbunada, Taghreed
AuthorYounes, Salma
AuthorOkashah, Sarah
AuthorEthiraj, Selvarajan
AuthorC, George Priya Doss
AuthorZayed, Hatem
Available date2020-11-05T09:36:56Z
Publication Date2020-10-01
Publication NameGenes
Identifierhttp://dx.doi.org/10.3390/genes11111256
CitationS, U.K.; Rajan, B.; D, T.K.; V, A.P.; Abunada, T.; Younes, S.; Okashah, S.; Ethiraj, S.; C, G.P.D.; Zayed, H. Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity. Genes 2020, 11, 1256.
URIhttp://hdl.handle.net/10576/16934
Abstract(1) Aims: Diabesity, defined as diabetes occurring in the context of obesity, is a serious health problem that is associated with an increased risk of premature heart attack, stroke, and death. To date, a key challenge has been to understand the molecular pathways that play significant roles in diabesity. In this study, we aimed to investigate the genetic links between diabetes and obesity in diabetic individuals and highlight the role(s) of shared genes in individuals with diabesity. (2) Methods: The interactions between the genes were analyzed using the Search Tool for the Retrieval of Interacting Genes (STRING) tool after the compilation of obesity genes associated with type 1 diabetes (T1D), type 2 diabetes (T2D), and maturity-onset diabetes of the young (MODY). Cytoscape plugins were utilized for enrichment analysis. (3) Results: We identified 546 obesity genes that are associated with T1D, T2D, and MODY. The network backbone of the identified genes comprised 514 nodes and 4126 edges with an estimated clustering coefficient of 0.242. The Molecular Complex Detection (MCODE) generated three clusters with a score of 33.61, 16.788, and 6.783, each. The highest-scoring nodes of the clusters were , , and genes. The genes from cluster 1 were enriched in FOXO-mediated transcription of oxidative stress, renin secretion, and regulation of lipolysis in adipocytes. The cluster 2 genes enriched in Src homology 2 domain-containing (SHC)-related events triggered by , regulation of lipolysis in adipocytes, and GRB2: SOS produce a link to mitogen-activated protein kinase (MAPK) signaling for integrins. The cluster 3 genes ere enriched in IGF1R signaling cascade and insulin signaling pathway. (4) Conclusion: This study presents a platform to discover potential targets for diabesity treatment and helps in understanding the molecular mechanism.
SponsorThe APC was funded by Qatar University Internal Grant number [QUST-2-CHS-2020-12]
Languageen
PublisherMDPI
SubjectMODY
T1D
T2D
diabesity
diabetes
obesity
protein-protein interaction
TitleInvolvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity
TypeArticle
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record