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المؤلفZachariah, Matshediso
المؤلفMaamoun, Hatem
المؤلفMilano, Larissa
المؤلفRayman, Margaret P.
المؤلفMeira, Lisiane B.
المؤلفAgouni, Abdelali
تاريخ الإتاحة2020-12-21T10:45:19Z
تاريخ النشر2020-01-01
اسم المنشورJournal of Cellular Physiology
المعرّفhttp://dx.doi.org/10.1002/jcp.30175
الاقتباسZachariah, M, Maamoun, H, Milano, L, Rayman, MP, Meira, LB, Agouni, A. Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium. J Cell Physiol. 2020; 1– 12. https://doi.org/10.1002/jcp.30175
الرقم المعياري الدولي للكتاب00219541
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85096647041&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/17227
الملخصSelenium is an essential trace element important for human health. A balanced intake is, however, crucial to maximize the health benefits of selenium. At physiological concentrations, selenium mediates antioxidant, anti-inflammatory, and pro-survival actions. However, supra-nutritional selenium intake was associated with increased diabetes risk leading potentially to endothelial dysfunction, the initiating step in atherosclerosis. High selenium causes apoptosis in cancer cells via endoplasmic reticulum (ER) stress, a mechanism also implicated in endothelial dysfunction. Nonetheless, whether ER stress drives selenium-induced endothelial dysfunction, remains unknown. Here, we investigated the effects of increasing concentrations of selenium on endothelial cells. High selenite reduced nitric oxide bioavailability and impaired angiogenesis. High selenite also induced ER stress, increased reactive oxygen species (ROS) production, and apoptosis. Pretreatment with the chemical chaperone, 4-phenylbutyrate, prevented the toxic effects of selenium. Our findings support a model where high selenite leads to endothelial dysfunction through activation of ER stress and increased ROS production. These results highlight the importance of tailoring selenium supplementation to achieve maximal health benefits and suggest that prophylactic use of selenium supplements as antioxidants may entail risk.
اللغةen
الناشرWiley
الموضوعapoptosis
endoplasmic-reticulum stress
endothelial dysfunction
oxidative stress
selenium
العنوانEndoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium
النوعArticle
dc.accessType Open Access


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