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AuthorHassani, A
AuthorHussain, S A
AuthorEnezei, H H
AuthorSaeed, S
AuthorIbrahim, W N
AuthorAl-Qubaisi, M S
AuthorZentou, H
AuthorRosli, R
AuthorDoolaanea, A A
Available date2021-01-03T08:33:10Z
Publication Date2020-12-22
Publication NameIOP Conference Series: Materials Science and Engineering (MSE)
Identifierhttp://dx.doi.org/10.1088/1757-899X/991/1/012101
CitationA Hassani et al 2020 IOP Conf. Ser.: Mater. Sci. Eng. 991 012101
ISSN1757-8981
URIhttp://hdl.handle.net/10576/17260
AbstractCurcumin nanoparticles (Cur/GANPs) were formulated based on gum arabic (GA) as a stabilizer coatings for nanoparticles through efficient synthesis approach. The current study investigated the antioxidant properties and antihypertensive activity of curcumin (Cur) using various established in vitro assays, such as 1,1-diphenyl-2-picrylhydrazyl (DPPH) as well as angiotensin converting enzyme (ACE) inhibitory activity. The in vitro cytotoxicity of Cur/GANPs against human liver cancer (HepG2), and colon cancer (HT29) was investigated. The exposure of human cancer cells to Cur/GANPs (1.56-100 µg/ml) using MTT (3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyl tetrazolium bromide) has revealed that the Cur/GANPs inhibited the growth of cell lines examined in a dose dependent manner. Hence, Cur/GANPs nanoparticles may have great potential to be applied for cancer treatment.
SponsorThe authors would like to acknowledge International Islamic University Malaysia and Universiti Putra Malaysia for awarding the funds to conduct this research under project number of P-RIGS18-026-0026 and GP-IPS/2016/9505500
Languageen
PublisherIOP Publishing
Subjectnanoparticles
Cancer
gum arabic
TitleFormulation and antioxidant properties of curcumin gum Arabic nanoparticles for delivery to cancer cells
TypeArticle
Volume Number991
ESSN1757-899X
dc.accessType Open Access


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