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AuthorYounes, Nadin
AuthorSyed, Najeeb
AuthorYadav, Santosh K
AuthorHaris, Mohammad
AuthorAbdallah, Atiyeh M
AuthorAbu-Madi, Marawan
Available date2021-01-14T06:30:20Z
Publication Date2021-01-07
Publication NameJournal of Personalized Medicine
Identifierhttp://dx.doi.org/10.3390/jpm11010034
CitationYounes, N.; Syed, N.; Yadav, S.K.; Haris, M.; Abdallah, A.M.; Abu-Madi, M. A Whole-Genome Sequencing Association Study of Low Bone Mineral Density Identifies New Susceptibility Loci in the Phase I Qatar Biobank Cohort. J. Pers. Med. 2021, 11, 34.
URIhttp://hdl.handle.net/10576/17307
AbstractBone density disorders are characterized by a reduction in bone mass density and strength, which lead to an increase in the susceptibility to sudden and unexpected fractures. Despite the serious consequences of low bone mineral density (BMD) and its significant impact on human health, most affected individuals may not know that they have the disease because it is asymptomatic. Therefore, understanding the genetic basis of low BMD and osteoporosis is essential to fully elucidate its pathobiology and devise preventative or therapeutic approaches. Here we sequenced the whole genomes of 3000 individuals from the Qatar Biobank and conducted genome-wide association analyses to identify genetic risk factors associated with low BMD in the Qatari population. Fifteen variants were significantly associated with total body BMD ( < 5 × 10). Of these, five variants had previously been reported by and were directionally consistent with previous genome-wide association study data. Ten variants were new: six intronic variants located at six gene loci (MALAT1/TALAM1, FASLG, LSAMP, SAG, FAM189A2, and LOC101928063) and four intergenic variants. This first such study in Qatar provides a new insight into the genetic architecture of low BMD in the Qatari population. Nevertheless, more studies are needed to validate these findings and to elucidate the functional effects of these variants on low BMD and bone fracture susceptibility.
SponsorQUST-1-CHS-2019-16
Languageen
PublisherMDPI
SubjectQatar
Qatar Biobank
bone mineral density
genome-wide association
osteoporosis
whole-genome sequencing
TitleA Whole-Genome Sequencing Association Study of Low Bone Mineral Density Identifies New Susceptibility Loci in the Phase I Qatar Biobank Cohort.
TypeArticle
Issue Number1
Volume Number11
ESSN2075-4426
dc.accessType Open Access


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