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المؤلفB. , Thomas
المؤلفM., Mohamed
المؤلفM., Al Hail
المؤلفFA., Awwad
المؤلفRM., Wahba
المؤلفSB., Hassan
المؤلفK., Omar
المؤلفW., El Kassem
المؤلفP., Abdul Rouf
تاريخ الإتاحة2021-03-25T11:33:35Z
تاريخ النشر2016
اسم المنشورClinical Pharmacology: Advances and Applications
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.2147/CPAA.S106234
معرّف المصادر الموحدhttp://hdl.handle.net/10576/18003
الملخصWe report a case of 22-year-old primigravida presented to Women's Hospital - Hamad Medical Corporation emergency with severe epigastric pain, nausea, and vomiting. On admission, she was dehydrated with remarkably worsening symptoms. Laboratory findings revealed significantly elevated liver enzymes with unknown etiology. Her past medical history showed an admission for nausea and vomiting 3 weeks previously and she was discharged on antiemetics, and esomeprazole for the first time. Due to the predominantly elevated liver enzymes, the clinical pharmacist discussed the possibility of esomeprazole-induced adverse effects and suggested to suspend esomeprazole based on the evidence from literature review. The liver enzymes showed a substantial improvement within days after the discontinuation of the drug; however, a rechallenge was not done since it could have adversely affected the mother or the fetus. Using the Naranjo Adverse Drug Reaction Probability scales, the adverse reaction due to esomeprazole was classified as "probably".
اللغةen
الناشرDove Medical Press Ltd
الموضوعalanine aminotransferase
alkaline phosphatase
aspartate aminotransferase
esomeprazole
metoclopramide
pantoprazole
pyridoxine
adult
Article
autoimmune liver disease
case report
decreased appetite
dehydration
differential diagnosis
disease severity
drug substitution
drug withdrawal
epigastric pain
female
follow up
general condition deterioration
human
hyperemesis gravidarum
hypertransaminasemia
laboratory test
liver function
Mallory Weiss syndrome
medical history
nausea and vomiting
pregnant woman
primigravida
toxic hepatitis
virus hepatitis
weight reduction
young adult
العنوانA case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis
النوعArticle
الصفحات199-202
رقم المجلد8
dc.accessType Abstract Only


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