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AuthorB. , Thomas
AuthorM., Mohamed
AuthorM., Al Hail
AuthorFA., Awwad
AuthorRM., Wahba
AuthorSB., Hassan
AuthorK., Omar
AuthorW., El Kassem
AuthorP., Abdul Rouf
Available date2021-03-25T11:33:35Z
Publication Date2016
Publication NameClinical Pharmacology: Advances and Applications
ResourceScopus
URIhttp://dx.doi.org/10.2147/CPAA.S106234
URIhttp://hdl.handle.net/10576/18003
AbstractWe report a case of 22-year-old primigravida presented to Women's Hospital - Hamad Medical Corporation emergency with severe epigastric pain, nausea, and vomiting. On admission, she was dehydrated with remarkably worsening symptoms. Laboratory findings revealed significantly elevated liver enzymes with unknown etiology. Her past medical history showed an admission for nausea and vomiting 3 weeks previously and she was discharged on antiemetics, and esomeprazole for the first time. Due to the predominantly elevated liver enzymes, the clinical pharmacist discussed the possibility of esomeprazole-induced adverse effects and suggested to suspend esomeprazole based on the evidence from literature review. The liver enzymes showed a substantial improvement within days after the discontinuation of the drug; however, a rechallenge was not done since it could have adversely affected the mother or the fetus. Using the Naranjo Adverse Drug Reaction Probability scales, the adverse reaction due to esomeprazole was classified as "probably".
Languageen
PublisherDove Medical Press Ltd
Subjectalanine aminotransferase
alkaline phosphatase
aspartate aminotransferase
esomeprazole
metoclopramide
pantoprazole
pyridoxine
adult
Article
autoimmune liver disease
case report
decreased appetite
dehydration
differential diagnosis
disease severity
drug substitution
drug withdrawal
epigastric pain
female
follow up
general condition deterioration
human
hyperemesis gravidarum
hypertransaminasemia
laboratory test
liver function
Mallory Weiss syndrome
medical history
nausea and vomiting
pregnant woman
primigravida
toxic hepatitis
virus hepatitis
weight reduction
young adult
TitleA case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis
TypeArticle
Pagination199-202
Volume Number8
dc.accessType Abstract Only


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