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AuthorRazali, Khairiah
AuthorOthman, Noratikah
AuthorMohd Nasir, Mohd Hamzah
AuthorDoolaanea, Abd Almonem
AuthorKumar, Jaya
AuthorIbrahim, Wisam Nabeel
AuthorIbrahim, Norlinah Mohamed
AuthorMohamed, Wael M. Y.
Available date2021-04-18T11:01:02Z
Publication Date2021-04-15
Publication NameFrontiers in Genetics
Identifierhttp://dx.doi.org/10.3389/fgene.2021.655550
CitationRazali K, Othman N, Mohd Nasir MH, Doolaanea AA, Kumar J, Ibrahim WN, Mohamed Ibrahim N and Mohamed WMY (2021) The Promise of the Zebrafish Model for Parkinson’s Disease: Today’s Science and Tomorrow’s Treatment. Front. Genet. 12:655550. doi: 10.3389/fgene.2021.655550
URIhttp://hdl.handle.net/10576/18278
AbstractThe second most prevalent neurodegenerative disorder in the elderly is Parkinson’s disease (PD). Its etiology is unclear and there are no available disease-modifying medicines. Therefore, more evidence is required concerning its pathogenesis. The use of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the basis of most animal models of PD. MPTP is metabolized by monoamine oxidase B (MAO B) to MPP + and induces the loss of dopaminergic neurons in the substantia nigra in mammals. Zebrafish have been commonly used in developmental biology as a model organism, but owing to its perfect mix of properties, it is now emerging as a model for human diseases. Zebrafish (Danio rerio) are cheap and easy to sustain, evolve rapidly, breed transparent embryos in large amounts, and are readily manipulated by different methods, particularly genetic ones. Furthermore, zebrafish are vertebrate species and mammalian findings obtained from zebrafish may be more applicable than those derived from genetic models of invertebrates such as Drosophila melanogaster and Caenorhabditis elegans. The resemblance cannot be taken for granted, however. The goal of the present review article is to highlight the promise of zebrafish as a PD animal model. As its aminergic structures, MPTP mode of action, and PINK1 roles mimic those of mammalians, zebrafish seems to be a viable model for studying PD. The roles of zebrafish MAO, however, vary from those of the two types of MAO present in mammals. The benefits unique to zebrafish, such as the ability to perform large-scale genetic or drug screens, should be exploited in future experiments utilizing zebrafish PD models.
Languageen
PublisherFrontiers Media
SubjectParkinson’s Disease
zebraafish
TitleThe Promise of the Zebrafish Model for Parkinson’s Disease: Today’s Science and Tomorrow’s Treatment
TypeArticle
Volume Number12
ESSN1664-8021
dc.accessType Open Access


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