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AuthorNeoh, Chin Fen
AuthorLeung, Lok
AuthorChan, Elsie
AuthorAl-Badriyeh, Daoud
AuthorFullinfaw, Robert O.
AuthorJhanji, Vishal
AuthorVajpayee, Rasik B.
AuthorDavies, Geoffrey E.
AuthorStewart, Kay
AuthorKong, David C. M.
Available date2021-04-22T13:00:31Z
Publication Date2016
Publication NameAntimicrobial Agents and Chemotherapy
ResourceScopus
URIhttp://dx.doi.org/10.1128/AAC.00683-16
URIhttp://hdl.handle.net/10576/18345
AbstractTwenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis.
Languageen
PublisherAmerican Society for Microbiology
Subjecteye drops
voriconazole
antifungal agent
eye drops
voriconazole
adult
aged
aqueous humor
Article
cataract extraction
clinical article
drug absorption
drug clearance
drug elimination
drug half life
elective surgery
elimination half-life
elimination rate constant
female
high performance liquid chromatography
human
in vitro study
infection prevention
keratomycosis
male
middle aged
minimum inhibitory concentration
open study
paracentesis
postoperative infection
priority journal
very elderly
clinical trial
drug effects
Adult
Aged
Aged, 80 and over
Antifungal Agents
Aqueous Humor
Cataract Extraction
Female
Humans
Male
Middle Aged
Ophthalmic Solutions
Voriconazole
TitleOpen-label study of absorption and clearance of 1% voriconazole eye drops
TypeArticle
Pagination6896-6898
Issue Number11
Volume Number60
dc.accessType Abstract Only


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