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المؤلفRudokas, M.
المؤلفNajlah, M.
المؤلفAlhnan, M.A.
المؤلفElhissi, A.
تاريخ الإتاحة2021-09-01T10:02:49Z
تاريخ النشر2016
اسم المنشورMedical Principles and Practice
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.1159/000445116
معرّف المصادر الموحدhttp://hdl.handle.net/10576/22422
الملخصThis is a critical review on research conducted in the field of pulmonary delivery of liposomes. Issues relating to the mechanism of nebulisation and liposome composition were appraised and correlated with literature reports of liposome formulations used in clinical trials to understand the role of liposome size and composition on therapeutic outcome. A major highlight was liposome inhalation for the treatment of lung cancers. Many in vivo studies that explored the potential of liposomes as anticancer carrier systems were evaluated, including animal studies and clinical trials. Liposomes can entrap anticancer drugs and localise their action in the lung following pulmonary delivery. The safety of inhaled liposomes incorporating anticancer drugs depends on the anticancer agent used and the amount of drug delivered to the target cancer in the lung. The difficulty of efficient targeting of liposomal anticancer aerosols to the cancerous tissues within the lung may result in low doses reaching the target site. Overall, following the success of liposomes as inhalable carriers in the treatment of lung infections, it is expected that more focus from research and development will be given to designing inhalable liposome carriers for the treatment of other lung diseases, including pulmonary cancers. The successful development of anticancer liposomes for inhalation may depend on the future development of effective aerosolisation devices and better targeted liposomes to maximise the benefit of therapy and reduce the potential for local and systemic adverse effects. 2016 S. Karger AG, Basel.
اللغةen
الناشرS. Karger AG
الموضوعamikacin
liposome
antineoplastic agent
antineoplastic antibiotic
cisplatin
doxorubicin
drug carrier
liposome
macrogol derivative
Conference Paper
drug classification
drug formulation
drug safety
drug stability
dry powder inhaler
human
in vivo study
liposomal delivery
lung cancer
lung infection
medical nebulizer
metered dose inhaler
soft mist inhaler
analogs and derivatives
animal
chemistry
drug delivery system
inhalational drug administration
Lung Neoplasms
procedures
Administration, Inhalation
Animals
Antibiotics, Antineoplastic
Antineoplastic Agents
Cisplatin
Doxorubicin
Drug Carriers
Drug Delivery Systems
Humans
Liposomes
Lung Neoplasms
Polyethylene Glycols
العنوانLiposome Delivery Systems for Inhalation: A Critical Review Highlighting Formulation Issues and Anticancer Applications
النوعConference Paper
الصفحات60-72
رقم العدد2
رقم المجلد25
dc.accessType Open Access


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