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AuthorRahhal, Alaa
AuthorKhir, Fadi
AuthorOrabi, Bassant
AuthorChbib, Salma
AuthorAl-Khalaila, Osama
AuthorSalah Abdelghani, Mohamed
AuthorOsman, Omnia
AuthorAzzam Ashour, Amr
AuthorAl-Awad, Mohammad
AuthorMahfouz, Ahmed
AuthorAwaisu, Ahmed
AuthorHussien Aljundi, Amer
AuthorAlahmad, Yaser
AuthorAlyafei, Sumaya
AuthorRahman Arabi, Abdul
Available date2021-10-28T10:00:54Z
Publication Date2021-08
Publication NameCurrent Problems in Cardiology
Identifierhttp://dx.doi.org/10.1016/j.cpcardiol.2021.100956
CitationRahhal, A., Khir, F., Orabi, B., Chbib, S., Al-Khalaila, O., Abdelghani, M. S., Osman, O., Ashour, A. A., Al-Awad, M., Mahfouz, A., Awaisu, A., Aljundi, A. H., Alahmad, Y., Alyafei, S., & Arabi, A. R. (2021). A Comparative Study of High-intensity Rosuvastatin Versus Atorvastatin Therapy Post-acute Coronary Syndrome Using Real-world Data. Current Problems in Cardiology, 100956. https://doi.org/10.1016/j.cpcardiol.2021.100956
ISSN0146-2806
URIhttp://hdl.handle.net/10576/24710
AbstractA high-intensity statin is recommended for the secondary prevention of cardiovascular diseases (CVD). However, real-world evidence of the effectiveness of rosuvastatin following acute coronary syndrome (ACS) is scarce. This retrospective cohort study included patients diagnosed with ACS to compare between the 2 high-intensity statin therapies (rosuvastatin vs atorvastatin) in terms of a primary composite outcome of CVD-associated death, non-fatal ACS, and non-fatal stroke at 1 month and 12 months post discharge. The primary effectiveness outcome did not differ between the 2 groups at 1 month (1.3% vs 1%; aHR = 1.64, 95% CI 0.55-4.94, P= 0.379) and at 12 months (4.8% vs 3.5%; aHR = 1.48, 95% CI 0.82-2.67, P= 0.199). Similarly, the 2 groups had comparable safety outcomes. In conclusion, the use of high-intensity rosuvastatin compared to high-intensity atorvastatin therapy in patients with ACS had resulted in comparable cardiovascular effectiveness and safety outcomes.
Languageen
PublisherElsevier
SubjectAtorvastatin Therapy
High-intensity Rosuvastatin
TitleA Comparative Study of High-intensity Rosuvastatin Versus Atorvastatin Therapy Post-acute Coronary Syndrome Using Real-world Data
TypeArticle
dc.accessType Open Access


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