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المؤلفLhamyani, Said
المؤلفGentile, Adriana-Mariel
المؤلفGiráldez-Pérez, Rosa M
المؤلفFeijóo-Cuaresma, Mónica
المؤلفRomero-Zerbo, Silvana Yanina
المؤلفClemente-Postigo, Mercedes
المؤلفZayed, Hatem
المؤلفOlivera, Wilfredo Oliva
المؤلفBermúdez-Silva, Francisco Javier
المؤلفSalas, Julián
المؤلفGómez, Carlos López
المؤلفHmadcha, Abdelkrim
المؤلفHajji, Nabil
المؤلفOlveira, Gabriel
المؤلفTinahones, Francisco J
المؤلفEl Bekay, Rajaa
تاريخ الإتاحة2021-11-29T09:35:25Z
تاريخ النشر2021-12-03
اسم المنشورMolecular Therapy Nucleic Acids
المعرّفhttp://dx.doi.org/10.1016/j.omtn.2021.06.019
الاقتباسSaid Lhamyani et. al. miR-21 mimic blocks obesity in mice: A novel therapeutic option, Molecular Therapy - Nucleic Acids, Volume 26, 2021, Pages 401-416, ISSN 2162-2531, https://doi.org/10.1016/j.omtn.2021.06.019.
الرقم المعياري الدولي للكتاب2162-2531
معرّف المصادر الموحدhttp://hdl.handle.net/10576/25184
الملخصMicroRNAs (miRNAs) are promising drug targets for obesity and metabolic disorders. Recently, miRNA mimics are providing a unique mechanism of action that guides the process for drug development and sets out the context of their therapeutic application. miRNA (miR)-21 expression in white adipose tissue (WAT) has been associated with obesity. We aimed to analyze miR-21 expression levels in relation to diabetes and obesity to determine the effect that miR-21 mimic has on processes involved in WAT functionality, to dissect the underlying molecular mechanisms, and to study the potential therapeutic application of the miR-21 mimic against obesity. We found higher miR-21 levels in WAT from non-diabetic obese compared to normoweight humans and mice. Moreover, in 3T3-L1 adipocytes, miR-21 mimic affect genes involved in WAT functionality regulation and significantly increase the expression of genes involved in browning and thermogenesis. Interestingly, treatment with the miR-21 mimic blocked weight gain induced by a high-fat diet in obese mice, without modifying food intake or physical activity. This was associated with metabolic enhancement, WAT browning, and brown adipose tissue (AT) thermogenic programming through vascular endothelial growth factor A (VEGF-A), p53, and transforming growth factor β1 (TGF-β1) signaling pathways. Our findings suggest that miR-21 mimic-based therapy may provide a new opportunity to therapeutically manage obesity and consequently, its associated alterations.
اللغةen
الناشرElsevier
الموضوعTMEM26
adipose tissue
brown adipose tissue
browning
diabetes
metabolism
miR-21
obesity
thermogenesis
uncoupling protein 1
العنوانmiR-21 mimic blocks obesity in mice: A novel therapeutic option
النوعArticle
الصفحات401-416
رقم المجلد26
dc.accessType Open Access


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