CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study
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التاريخ
2021-10-01المؤلف
Lima, Suelen CristinaGomes da Silva, Isaura Isabelle Fonseca
Nascimento, Denise de Queiroga
de Moura, Ronald Rodrigues
Mesquita, Matheus da Silva
Asano, Nadja Maria Jorge
Fernandes, Gisele Vagjel
Valente, Lucila Maria
Rushansky, Eliezer
Mariano, Maria Helena Queiroz de Araújo
Xavier, Ricardo Machado
Chies, José Artur Bogo
Crovella, Sergio
Sandrin-Garcia, Paula
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are influenced by genetic variants in immune system HLA genes. The Class II Major Histocompatibility Complex Transactivator (CIITA) is an important co-activator of the HLA transcriptional complex; the single nucleotide variant (SNV) rs3087456 localized in the gene promoter region (−168 A/G) has been reported as able to modify its transcription level. In our study, we assessed CIITA rs3087456 SNV in 1,044 Brazilians from two Brazilian regions (Northeast and South) to verify the association with susceptibility and clinical manifestations of (SLE) and (RA) using TaqMan SNP Genotyping Assays System. We observed a protection for a recessive model (GG x AA+AG) for RA susceptibility and increased risk for erosion development in AG genotype patients. No significant association was observed for SLE susceptibility; however, we observed significant increased risk for Class IV and V nephritis development in G allele and GG genotype patients. In conclusion, we showed the contribution of CIITA rs3087456 to SLE or RA clinical features and RA susceptibility in the studied populations.
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85115172117&origin=inwardالمجموعات
- العلوم البيولوجية والبيئية [856 items ]