CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study
المؤلف | Lima, Suelen Cristina |
المؤلف | Gomes da Silva, Isaura Isabelle Fonseca |
المؤلف | Nascimento, Denise de Queiroga |
المؤلف | de Moura, Ronald Rodrigues |
المؤلف | Mesquita, Matheus da Silva |
المؤلف | Asano, Nadja Maria Jorge |
المؤلف | Fernandes, Gisele Vagjel |
المؤلف | Valente, Lucila Maria |
المؤلف | Rushansky, Eliezer |
المؤلف | Mariano, Maria Helena Queiroz de Araújo |
المؤلف | Xavier, Ricardo Machado |
المؤلف | Chies, José Artur Bogo |
المؤلف | Crovella, Sergio |
المؤلف | Sandrin-Garcia, Paula |
تاريخ الإتاحة | 2022-01-25T07:10:21Z |
تاريخ النشر | 2021-10-01 |
اسم المنشور | International Journal of Immunogenetics |
المعرّف | http://dx.doi.org/10.1111/iji.12548 |
الاقتباس | Lima, S. C., Gomes da Silva, I. I. F., Nascimento, D. D. Q., de Moura, R. R., Mesquita, M. D. S., Asano, N. M. J., Fernandes, G. V., Valente, L. M., Rushansky, E., Mariano, M. H. Q. D. A., Xavier, R. M., Chies, J. A. B., Crovella, S., & Sandrin-Garcia, P. (2021). CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study. International Journal of Immunogenetics, 48, 429– 434. https://doi.org/10.1111/iji.12548 |
الرقم المعياري الدولي للكتاب | 17443121 |
الملخص | Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are influenced by genetic variants in immune system HLA genes. The Class II Major Histocompatibility Complex Transactivator (CIITA) is an important co-activator of the HLA transcriptional complex; the single nucleotide variant (SNV) rs3087456 localized in the gene promoter region (−168 A/G) has been reported as able to modify its transcription level. In our study, we assessed CIITA rs3087456 SNV in 1,044 Brazilians from two Brazilian regions (Northeast and South) to verify the association with susceptibility and clinical manifestations of (SLE) and (RA) using TaqMan SNP Genotyping Assays System. We observed a protection for a recessive model (GG x AA+AG) for RA susceptibility and increased risk for erosion development in AG genotype patients. No significant association was observed for SLE susceptibility; however, we observed significant increased risk for Class IV and V nephritis development in G allele and GG genotype patients. In conclusion, we showed the contribution of CIITA rs3087456 to SLE or RA clinical features and RA susceptibility in the studied populations. |
اللغة | en |
الناشر | Wiley |
الموضوع | human leukocyte antigen (HLA) MHC2TA rheumatoid arthritis single nucleotide variation systemic lupus erythematosus |
النوع | Other |
الصفحات | 429-434 |
رقم العدد | 5 |
رقم المجلد | 48 |
ESSN | 1744-313X |
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