CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study
Author | Lima, Suelen Cristina |
Author | Gomes da Silva, Isaura Isabelle Fonseca |
Author | Nascimento, Denise de Queiroga |
Author | de Moura, Ronald Rodrigues |
Author | Mesquita, Matheus da Silva |
Author | Asano, Nadja Maria Jorge |
Author | Fernandes, Gisele Vagjel |
Author | Valente, Lucila Maria |
Author | Rushansky, Eliezer |
Author | Mariano, Maria Helena Queiroz de Araújo |
Author | Xavier, Ricardo Machado |
Author | Chies, José Artur Bogo |
Author | Crovella, Sergio |
Author | Sandrin-Garcia, Paula |
Available date | 2022-01-25T07:10:21Z |
Publication Date | 2021-10-01 |
Publication Name | International Journal of Immunogenetics |
Identifier | http://dx.doi.org/10.1111/iji.12548 |
Citation | Lima, S. C., Gomes da Silva, I. I. F., Nascimento, D. D. Q., de Moura, R. R., Mesquita, M. D. S., Asano, N. M. J., Fernandes, G. V., Valente, L. M., Rushansky, E., Mariano, M. H. Q. D. A., Xavier, R. M., Chies, J. A. B., Crovella, S., & Sandrin-Garcia, P. (2021). CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: A population-based cohort study. International Journal of Immunogenetics, 48, 429– 434. https://doi.org/10.1111/iji.12548 |
ISSN | 17443121 |
Abstract | Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are influenced by genetic variants in immune system HLA genes. The Class II Major Histocompatibility Complex Transactivator (CIITA) is an important co-activator of the HLA transcriptional complex; the single nucleotide variant (SNV) rs3087456 localized in the gene promoter region (−168 A/G) has been reported as able to modify its transcription level. In our study, we assessed CIITA rs3087456 SNV in 1,044 Brazilians from two Brazilian regions (Northeast and South) to verify the association with susceptibility and clinical manifestations of (SLE) and (RA) using TaqMan SNP Genotyping Assays System. We observed a protection for a recessive model (GG x AA+AG) for RA susceptibility and increased risk for erosion development in AG genotype patients. No significant association was observed for SLE susceptibility; however, we observed significant increased risk for Class IV and V nephritis development in G allele and GG genotype patients. In conclusion, we showed the contribution of CIITA rs3087456 to SLE or RA clinical features and RA susceptibility in the studied populations. |
Language | en |
Publisher | Wiley |
Subject | human leukocyte antigen (HLA) MHC2TA rheumatoid arthritis single nucleotide variation systemic lupus erythematosus |
Type | Other |
Pagination | 429-434 |
Issue Number | 5 |
Volume Number | 48 |
ESSN | 1744-313X |
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