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AuthorBhat, Ajaz A
AuthorYousuf, Parvaiz
AuthorWani, Nissar A
AuthorRizwan, Arshi
AuthorChauhan, Shyam S
AuthorSiddiqi, Mushtaq A
AuthorBedognetti, Davide
AuthorEl-Rifai, Wael
AuthorFrenneaux, Michael P
AuthorBatra, Surinder K
AuthorHaris, Mohammad
AuthorMacha, Muzafar A
Available date2022-02-27T05:10:39Z
Publication Date2021-01-12
Publication NameSignal Transduction and Targeted Therapy
Identifierhttp://dx.doi.org/10.1038/s41392-020-00419-w
CitationBhat, A.A., Yousuf, P., Wani, N.A. et al. Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy. Sig Transduct Target Ther 6, 12 (2021). https://doi.org/10.1038/s41392-020-00419-w
URIhttp://hdl.handle.net/10576/27404
AbstractHead and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of HNSCC. Despite significant advances in multimodal therapeutic interventions, failure to cure and recurrence are common and account for most deaths. It is becoming increasingly apparent that tumor microenvironment (TME) plays a critical role in HNSCC tumorigenesis, promotes the evolution of aggressive tumors and resistance to therapy, and thereby adversely affects the prognosis. A complete understanding of the TME factors, together with the highly complex tumor-stromal interactions, can lead to new therapeutic interventions in HNSCC. Interestingly, different molecular and immune landscapes between HPV and HPV (human papillomavirus) HNSCC tumors offer new opportunities for developing individualized, targeted chemoimmunotherapy (CIT) regimen. This review highlights the current understanding of the complexity between HPV and HPV HNSCC TME and various tumor-stromal cross-talk modulating processes, including epithelial-mesenchymal transition (EMT), anoikis resistance, angiogenesis, immune surveillance, metastatic niche, therapeutic resistance, and development of an aggressive tumor phenotype. Furthermore, we summarize the recent developments and the rationale behind CIT strategies and their clinical applications in HPV and HPV HNSCC.
SponsorThis study was supported by Ramalingaswami Fellowship (Grant number: D.O.NO.BT/HRD/35/02/2006) from the Department of Biotechnology, Government of India, New Delhi to Muzafar A. Macha. Mohammad Haris is funded by a grant (5071012001) from Sidra Medicine Doha, Qatar. Ajaz A. Bhat is supported by Sidra Medicine internal grant (5011041002). We thank Dr. Vineeta Tanwar (Ohio State University, Columbus, Ohio, USA) for her professional assistance in editing the paper.
Languageen
PublisherSpringer Nature
SubjectCancer microenvironment
Head and neck cancer
TitleTumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy.
TypeArticle Review
Issue Number1
Volume Number6
ESSN2059-3635
dc.accessType Open Access


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