Is Curcumin at the Threshold of Therapeutic Effectiveness on Patients with Colon Cancer?- A Systematic Review
المؤلف | Shafei, L. K. I. A. |
المؤلف | Ibrahim, Mohamed Izham Mohamed |
المؤلف | Billa, N. |
تاريخ الإتاحة | 2022-04-10T10:25:30Z |
تاريخ النشر | 2021 |
اسم المنشور | Frontiers in Pharmacology |
المصدر | Scopus |
الملخص | Curcumin, obtained from curcuma longa, has been the subject of decades of scientific investigation on its therapeutic usefulness. It is reported to possess several therapeutic properties, of which anti-colon cancer is of interest in this review. Clinically however, curcumin has yet to firm up its place among established anti-colon cancer therapeutic contenders. We aimed to systematically review prevailing clinical evidence on the role of curcumin in colon cancer treatment. The review drawing from literature on clinical studies indicates fairly long term tolerability. No regression of tumor was reported when curcumin was the sole intervention. Increase in p53 level expression was reported in a placebo controlled study but no reduction in PGE2 or 5HETE. Pharmacokinetic data on healthy humans indicate that formulated curcumin delivery systems present significantly higher systemic bioavailability. It appears therefore that the clinical use of curcumin can potentially be realized only through appropriate formulation interventions. |
راعي المشروع | We acknowledge Qatar University grant number QUST-2-CPH-2020-6 in supporting the research. |
اللغة | en |
الناشر | Frontiers Media S.A. |
الموضوع | cancer clinical trial colon curcumin formulation nanoparticle delivery outcome measures systematic review |
النوع | Article Review |
رقم المجلد | 12 |
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